BACTEREMIA IN SUBJECTS WITH LIVER DISEASE COMPARED TO OTHER CHRONIC ILLNESS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 已有研究表明，在脓毒症患者中，肝功能衰竭与预后不良有关。肝脏通过网状内皮系统参与细菌清除。此外，库普弗细胞是全身感染过程中细胞因子的重要来源。我们的动物数据表明，肺炎和败血症小鼠模型的肝脏损伤程度(表现为ALT水平)与全身菌血症水平相关。此外，随着全身性菌血症水平的增加，死亡率也会增加。因此，我们假设肝病与细菌清除减少有关，细菌清除减少导致菌血症增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It has been shown that liver failure is associated with poor prognosis in patients with sepsis. The liver participates in bacterial clearance via the reticular-endothelial system. In addition, Kupffer cells are an important source of cytokines during systemic infection. Our animal data suggests that the degree of liver injury (manifest as level of ALT) in a murine model of pneumonia and sepsis correlates with the level of systemic bacteremia. In addition, as the levels of systemic bacteremia increase, the mortality increases as well. Therefore, we hypothesize that liver disease is associated with decreased bacterial clearance which results in increased bacteremia.