SEMEN QUALITY IN PARTNERS OF PREGNANT WOMEN AND PHTHALATES IN PREGNANT WOMEN

孕妇伴侣的精液质量和孕妇的邻苯二甲酸盐

• 批准号: 7376996
• 负责人: AMY E SPARKS
• 金额: $ 3.24万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376996
• 关键词: SEMEN; QUALITY; PARTNERS; PREGNANT; WOMEN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Study for Future Families I is two-fold. The first is to establish what "normal" sperm counts and hormone levels are and how long most couples take to conceive. Articles in medical journals have reported changes in sperm counts over the past several decades and many of these have reported that sperm counts have been dropping. There have been many theories about why these changes have occurred, but none of them has been convincing enough to be accepted. This study, which is being conducted in four European and four U.S. cities, will use the same methods to measure the sperm counts and hormones in all cities. All of these men will be of proven fertility because their partners will be pregnant at the time that the study is being conducted. This will allow the study's researchers to compute what "normal" levels are around the world at this point in time. The second purpose of this study is to identify environmental exposures, including exposure to pesticides that might affect either the production of sperm or the production of hormones needed to make sperm. There are many environmental and hazardous exposures that theoretically could change the way a male makes both sperm and the hormones that allow the testicles to work properly. This study will help determine whether the history of these exposures is different in couples that got pregnant quickly compared to those who took a long time to get pregnant. The purpose of the follow-up Study for Future Families II is to find out if exposure to phthalates during pregnancy or in early life affects early development to look at exposure to certain commonly used chemicals which can be measured in urine samples. These investigators will look to see if the phthalate levels in women's urine or serum during pregnancy or in their urine and breast milk after birth are related to the phthalate levels in the baby's urine. The phthalate levels in mother and baby will be related to the use of various products and to the development of the baby.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。未来家庭研究I的目的有两个。首先是确定“正常”的精子数量和激素水平以及大多数夫妇需要多长时间才能怀孕。在过去的几十年里，医学期刊上的文章报道了精子数量的变化，其中许多报道精子数量一直在下降。关于为什么会发生这些变化，有很多理论，但没有一个有足够的说服力被接受。这项研究在四个欧洲城市和四个美国城市进行，将使用相同的方法测量所有城市的精子数量和激素。所有这些男性都将被证明具有生育能力，因为他们的伴侣在研究进行时将怀孕。这将使研究人员能够计算出此时世界各地的“正常”水平。 本研究的第二个目的是确定环境暴露，包括暴露于可能影响精子产生或制造精子所需激素产生的杀虫剂。有许多环境和危险的暴露，理论上可以改变男性制造精子和激素的方式，使睾丸正常工作。这项研究将有助于确定这些接触的历史是否在快速怀孕的夫妇与那些花了很长时间才怀孕的夫妇之间有所不同。 未来家庭后续研究II的目的是了解在怀孕期间或早期生活中接触邻苯二甲酸酯是否会影响早期发育，以了解某些常用化学品的暴露情况，这些化学品可以在尿液样本中测量。这些研究人员将观察怀孕期间妇女尿液或血清中或出生后尿液和母乳中的邻苯二甲酸酯水平是否与婴儿尿液中的邻苯二甲酸酯水平有关。母亲和婴儿体内的邻苯二甲酸酯水平将与各种产品的使用和婴儿的发育有关。