ACQUISITION OF HUMAN HERPES VIRUS-8 IN INFANCY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。人类疱疹病毒8型(HHV-8)，又称卡波西氏肉瘤疱疹病毒(KSHV)，于1994年首次被发现。从艾滋病患者切除的卡波西肉瘤组织中检测到病毒序列。这种疱疹病毒与另一种人类疱疹病原体爱泼斯坦-巴尔病毒最相似。随后，其他几种疾病也被认为与HHV-8有关。一个关键问题是人们如何以及何时感染HHV-8。许多人类疱疹病毒是在儿童早期感染的，此后有数十年的潜伏期，然后在成年中后期出现。这项提案的目标是调查婴儿时期的HHV-8感染及其在美国出生的新生儿中的传播途径。该项目的总体目标是确定婴儿在出生第一年感染HHV-8的百分比。这些调查人员推测，在生命的第一年感染HHV-8的儿童比之前怀疑的要多。特别是，他们提出这种感染可能是在围产期或在生命的头几个月获得的。据推测，母亲的血液、产道中的分泌物或母乳可能会将传染性传递给新生儿。口腔上皮细胞是婴幼儿口腔中的易感细胞。此后，这种感染直到成年后期都是无症状的，除非这个人获得了免疫抑制的条件。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human herpes virus 8 (HHV-8), also called Kaposi's sarcoma herpesvirus (KSHV), was first described in 1994. The viral sequences were detected in tissues of Kaposi sarcoma removed from AIDS patients. This herpes virus is most similar to Epstein-Barr virus, another human herpes pathogen. Several other diseases have subsequently been linked to HHV-8. A key issue is how and when people acquire HHV-8 infection. Many human herpesviruses are acquired in early childhood and thereafter have decades long latency period before emerging in mid to late adulthood. The goal of this proposal is to investigate HHV-8 infection in infancy and its route of transmission in neonates born in the United States. The overall goal of this project is to determine the percent of infants who contract HHV-8 infection during the first year of life. These investigators postulate that HHV-8 infection is contracted in the first year of life in more children than previously suspected. In particular, they propose that the infection may be acquired perinatally or in the first few months of life. Presumably maternal blood, secretions in the birth canal, or breast milk would transfer infectivity to the newborn. Oral epithelial cells in the infants mouth are a susceptible cell. Thereafter, the infection would be asymptomatic until late adulthood, unless the person acquired an immunosuppressive condition.