COUPLING OF D-CHIRO-INOSITOL TO INSULIN IN NORMAL AND PCOS WOMEN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是测试正常女性和多囊卵巢综合征（PCOS）女性胰岛素和d -氨基肌醇分子之间的关系。作为一项先导性研究，具体目的是确定DCI-IPG生物活性是否与正常女性糖耐量试验中胰岛素分泌密切相关，而与PCOS女性糖耐量试验中胰岛素分泌不相关，选择性抑制胰腺胰岛素分泌是否影响DCI-IPG生物活性。是否使用长时间稳定状态血糖胰岛素钳逐步胰岛素输注对先前接受过二氮氧化合物治疗的妇女有生物活性影响。将正常女性和BMI匹配的多囊卵巢综合征女性进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to test the relationship between insulin and a molecule called D-chiro-inositol in normal women and women with polycystic ovary syndrome (PCOS). As a pilot study the specific aims are to determine whether DCI-IPG bioactivity closely correlates with insulin secretion during a glucose tolerance test in normal women, fails to correlate with insulin secretion in women with PCOS during a glucose tolerance test, whether selective inhibition of pancreatic insulin secretion effects DCI-IPG bioactivity, whether stepwise insulin infusion using long duration steady state euglycemic insulin clamp has a bioactivity effect on women previously treated with diazoxide. Normal women and BMI matched women with PCOS will be compared.