D- CHIRO-INOSITOL IS ABSORBED BUT NOT SYNTHESISED IN RODENTS

D- 手性肌醇在啮齿动物体内被吸收但不合成

• 批准号: 8168811
• 负责人: XI LIN
• 金额: $ 1.13万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168811
• 关键词: Alfalfa; Animal Feed; Computer Retrieval of Information on Scientific Projects Database; Diet; Funding; Grant; Inositol; Institution; Insulin; Laboratories; Laboratory Animals; Property; Reporting; Research; Research Personnel; Resources; Rodent; Source; United States National Institutes of Health; Water; Weight; mimetics; pinitol

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. d-chiro-inositol (DCI) and pinitol (1d-3-O-methyl-chiro-inositol) are distinctive inositols reported to possess insulin-mimetic properties. DCI-containing compounds are abundant in common laboratory animal feed. By GC-MS of 6 m-HCl hydrolysates, Purina Laboratory Rodent Diet 5001 (diet 5001) contained 0.23 % total DCI by weight with most found in the lucerne and soya meal components. In contrast, only traces of l-chiro-inositol were observed. The DCI moiety was present in a water-soluble non-ionic form of which most was shown to be pinitol.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 d-手性肌醇（DCI）和松醇（1d-3-O-甲基-手性肌醇）是据报道具有胰岛素模拟性质的独特肌醇。含DCI的化合物在普通实验室动物饲料中丰富。通过6 m-HCl水解产物的GC-MS，Purina Laboratory啮齿动物饲料5001（饲料5001）含有0.23重量%的总DCI，其中大部分存在于卢塞恩和大豆粉组分中。相比之下，仅观察到痕量的l-手性肌醇。DCI部分以水溶性非离子形式存在，其中大部分显示为松醇。