COMPENSATORY CHANGES IN RENAL SENESCENCE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是比较老年人和年轻人在单肾切除术（手术切除一个肾脏）后的肾功能。我们计划比较年轻和老年肾移植供者的肾功能。此外，我们计划研究因切除的肾脏中存在肾瘤而行非肾切除术的年轻和老年患者。众所周知，人类可以通过剩余肾脏的代偿性肥大来适应一个肾脏的损失，因为它适应恢复肾功能。过去的研究人员认为，肾功能会随着年龄的增长而下降，但最近的文献表明，并不是所有的人都会出现这种下降。此外，老年肾脏供者是否能在未切除肾后的剩余肾脏中进行与年轻肾脏供者相同程度的代偿尚不清楚：换句话说，在切除另一个肾脏后，老年肾脏是否能像年轻肾脏一样代偿。很少有试验报道这一点，在这些试验中，有相互矛盾的结果。我们希望调查健康活体供者肾脏捐献前后的肾功能（胰岛素清除率），目的是比较年轻供者和老年供者的结果。由于老年（60岁以上）肾脏供者的数量很少，我们将纳入因肾瘤肥大而进行非肾切除术的受试者，并研究这一人群中的老年和年轻患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to compare the kidney function in the aged versus the young, following uninephrectomy (surgical removal of one kidney). We plan to compare kidney function in young and aged kidney transplant donors. In addition, we plan to study young and aged patients who have undergone uninephrectomy as a result of hypernephroma in the removed kidney. It is well known that humans can adapt to the loss of one kidney, through compensatory hypertrophy of the remaining kidney as it adapts to restore renal function. Past investigators have suggested that kidney function declines with age, but recent literature suggests that not all humans are subject to this decline. Furthermore, it is unknown whether the aged kidney donor can undergo compensation, in the remaining kidney, to the same degree as the young kidney donor after uninephrectomy: in other words, can the aged kidney compensate as well as the young kidney, following removal of the other kidney. Very few trials have reported on this, and amongst these trials, there are contradictory findings. We wish to investigate kidney function (insulin clearance) before and after kidney donation in healthy living donors, with the purpose of comparing the findings in the young donors versus the old donors. Because the number of aged (60+ yrs) kidney donors is small, we will include subjects who have undergone uninephrectomy due to hypernephroma, and study old and younger patients in this population as well.