COMPENSATORY CHANGES IN RENAL SENESCENCE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to compare the kidney function in the aged versus the young, following uninephrectomy (surgical removal of one kidney). We plan to compare kidney function in young and aged kidney transplant donors. In addition, we plan to study young and aged patients who have undergone uninephrectomy as a result of hypernephroma in the removed kidney. It is well known that humans can adapt to the loss of one kidney, through compensatory hypertrophy of the remaining kidney as it adapts to restore renal function. Past investigators have suggested that kidney function declines with age, but recent literature suggests that not all humans are subject to this decline. Furthermore, it is unknown whether the aged kidney donor can undergo compensation, in the remaining kidney, to the same degree as the young kidney donor after uninephrectomy: in other words, can the aged kidney compensate as well as the young kidney, following removal of the other kidney. Very few trials have reported on this, and amongst these trials, there are contradictory findings. We wish to investigate kidney function (insulin clearance) before and after kidney donation in healthy living donors, with the purpose of comparing the findings in the young donors versus the old donors. Because the number of aged (60+ yrs) kidney donors is small, we will include subjects who have undergone uninephrectomy due to hypernephroma, and study old and younger patients in this population as well.