COCAINE AND ADHERENCE READINESS TREATMENT INTERVENTION DEVELOPMENT PILOT: CART 4

可卡因和依从性准备治疗干预开发试点：CART 4

• 批准号: 7375175
• 负责人: KAREN S INGERSOLL
• 金额: $ 13.13万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375175
• 关键词: COCAINE; ADHERENCE; READINESS; TREATMENT; INTERVENTION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is a pilot trial proposing that people completing the CART intervention will show more improvements in medication adherence behavior as measured by time-line follow-back procedures, and greater reduction in cocaine problem severity as measured on the ASI than the participants completing the informational video intervention. Also, that people completing the CART condition will show greater improvements on clinical markers of immune health. Many studies have found substance use to be associated with decreased HIV medication adherence. Unfortunately, many providers may assume that substance using individuals cannot be adherent to their medication, leading to a risk of withholding treatment universally from substance abusers. In addition, despite the effectiveness of drug treatment, substance abusers often choose not to use available treatment resources. Interventions that improve adherence to antiviral medications among people with HIV are urgently needed. Cocaine users, especially crack users, are at increased risk of contracting HIV and the prevalence of HIV in this group of drug users is high. Once infected with HIV, crack users are likely to be under-treated for HIV. HIV and cocaine use are two factors that reduce the likelihood of obtaining adequate healthcare. This project is a Stage 1 study; therefore, the final protocol for the pilot trial will evolve throughout the project phases following three preliminary studies. The goal of Stage 1 research is to develop novel interventions and assess their feasibility prior to proposing a Stage 2 efficacy trial. The proposed study is well suited to a Stage 1 project because there is a dearth of validated treatments for the combined problems of non-adherence and cocaine use among patients with HIV, requiring the development and testing of novel interventions in a small number of patients. This stage 1 study will yield important clinical innovations to improve the health of cocaine abusers with HIV. It will provide direction and methods for future research on improving adherence and reducing cocaine use in people with HIV, and will provide the materials needed before implementing a Stage 2 trial.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。这项研究是一项试点试验，提出与完成信息视频干预的参与者相比，完成 CART 干预的参与者在药物依从性行为方面（通过时间线随访程序衡量）将显示出更多改善，并且根据 ASI 衡量，可卡因问题严重程度会更大程度地降低。此外，完成 CART 条件的人将在免疫健康的临床指标上表现出更大的改善。许多研究发现药物滥用与艾滋病毒药物依从性下降有关。不幸的是，许多提供者可能认为药物滥用者无法坚持服药，从而导致普遍拒绝对药物滥用者进行治疗的风险。此外，尽管药物治疗有效，但药物滥用者往往选择不使用现有的治疗资源。迫切需要采取干预措施来提高艾滋病毒感染者抗病毒药物的依从性。可卡因吸食者，尤其是强效吸毒者，感染艾滋病毒的风险增加，并且该吸毒者群体的艾滋病毒感染率很高。一旦感染艾滋病毒，破解用户很可能得不到艾滋病毒治疗。艾滋病毒和可卡因的使用是降低获得充分医疗保健可能性的两个因素。 该项目是第一阶段研究；因此，试点试验的最终方案将在三项初步研究之后的整个项目阶段不断发展。第一阶段研究的目标是在提出第二阶段疗效试验之前开发新的干预措施并评估其可行性。拟议的研究非常适合第一阶段项目，因为缺乏针对艾滋病毒患者不依从和使用可卡因的综合问题的有效治疗方法，需要在少数患者中开发和测试新的干预措施。这项第一阶段研究将产生重要的临床创新，以改善感染艾滋病毒的可卡因滥用者的健康。它将为未来提高艾滋病毒感染者依从性和减少可卡因使用的研究提供方向和方法，并将提供实施第二阶段试验之前所需的材料。