FP AND SALMETEROL IN PREVENTING COPD EXACERBATIONS

FP 和沙美特罗预防 COPD 恶化

• 批准号: 7378641
• 负责人: Imre Noth
• 金额: $ 0.91万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378641
• 关键词: biopsy; blood; emphysema; fluid; infection; lung; proteins; respiratory disorder; respiratory reflex; salts; tissues; water

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. COPD stands for Chronic Obstructive Pulmonary Disease. COPD is a term that refers mainly to two closely related respiratory disorders that gradually take a person's breath away: chronic bronchitis and/or emphysema associated with airflow obstruction. The primary symptom of COPD is shortness of breath accompanied by a cough or wheezing. There is no cure for COPD, only treatment to ease the symptoms of this disease. However, researchers are not clear how this disease occurs. The easiest way to obtain researchable information is to take a broncoalveolar lavage (BAL) and or endobronchial biopsy sample since they contain cells, proteins (combination of amino acids that make-up cells) and other factors. A BAL sample is fluid produced by the lungs mixed with sterile (free from germs that cause infection) salt water. An endobronchial biopsy sample is a piece of lung tissue the size of a breadcrumb taken from the larger, closer air passages. The purpose of this study is to evaluate the blood and airway of subjects with mild to moderate COPD while undergoing standard treatment to better assess how these standard therapies work.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。 COPD 代表慢性阻塞性肺疾病。慢性阻塞性肺病这个术语主要指两种密切相关的呼吸系统疾病，它们逐渐让人无法呼吸：慢性支气管炎和/或与气流阻塞相关的肺气肿。慢性阻塞性肺病的主要症状是呼吸短促并伴有咳嗽或喘息。慢性阻塞性肺病无法治愈，只能通过治疗来缓解这种疾病的症状。然而，研究人员并不清楚这种疾病是如何发生的。 获得可研究信息的最简单方法是采集支气管肺泡灌洗液 (BAL) 和/或支气管内活检样本，因为它们含有细胞、蛋白质（构成细胞的氨基酸组合）和其他因子。 BAL 样本是肺部产生的液体，与无菌（不含引起感染的细菌）盐水混合。支气管内活检样本是从较大、较近的气道中取出的一块面包屑大小的肺组织。 本研究的目的是评估患有轻度至中度慢性阻塞性肺病的受试者在接受标准治疗时的血液和气道，以更好地评估这些标准疗法的效果。