FP AND SALMETEROL IN PREVENTING COPD EXACERBATIONS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。COPD代表慢性阻塞性肺疾病。COPD是一个术语，主要指两种密切相关的呼吸系统疾病，它们逐渐让人喘不过气来：慢性支气管炎和/或与气流阻塞相关的肺气肿。慢性阻塞性肺疾病的主要症状是呼吸急促，并伴有咳嗽或喘息。COPD没有治愈的方法，只有缓解这种疾病症状的治疗方法。然而，研究人员并不清楚这种疾病是如何发生的。获取可研究信息的最简单方法是采集支气管肺泡灌洗(BAL)和或支气管镜活检样本，因为它们含有细胞、蛋白质(组成细胞的氨基酸组合)和其他因素。BAL样本是肺部与无菌(没有引起感染的细菌)盐水混合产生的液体。支气管内活检样本是取自更大、更近的呼吸道的一块面包屑大小的肺组织。这项研究的目的是评估接受标准治疗的轻中度COPD患者的血液和呼吸道，以更好地评估这些标准治疗的效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. COPD stands for Chronic Obstructive Pulmonary Disease. COPD is a term that refers mainly to two closely related respiratory disorders that gradually take a person's breath away: chronic bronchitis and/or emphysema associated with airflow obstruction. The primary symptom of COPD is shortness of breath accompanied by a cough or wheezing. There is no cure for COPD, only treatment to ease the symptoms of this disease. However, researchers are not clear how this disease occurs. The easiest way to obtain researchable information is to take a broncoalveolar lavage (BAL) and or endobronchial biopsy sample since they contain cells, proteins (combination of amino acids that make-up cells) and other factors. A BAL sample is fluid produced by the lungs mixed with sterile (free from germs that cause infection) salt water. An endobronchial biopsy sample is a piece of lung tissue the size of a breadcrumb taken from the larger, closer air passages. The purpose of this study is to evaluate the blood and airway of subjects with mild to moderate COPD while undergoing standard treatment to better assess how these standard therapies work.