FP AND SALMETEROL IN PREVENTING COPD EXACERBATIONS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。COPD是慢性阻塞性肺疾病的缩写。COPD是一个术语，主要指两种密切相关的呼吸系统疾病，逐渐使人无法呼吸：慢性支气管炎和/或肺气肿伴气流阻塞。慢性阻塞性肺病的主要症状是呼吸短促并伴有咳嗽或喘息。慢性阻塞性肺病无法治愈，只能通过治疗来缓解这种疾病的症状。然而，研究人员并不清楚这种疾病是如何发生的。获取可研究信息的最简单方法是取支气管滤泡灌洗（BAL）和/或支气管活检样本，因为它们含有细胞、蛋白质（构成细胞的氨基酸的组合）和其他因素。BAL样本是由肺部产生的液体与无菌（无引起感染的细菌）盐水混合。支气管活检样本是一块面包屑大小的肺组织，取自较大、较近的空气通道。本研究的目的是评估轻度至中度COPD患者在接受标准治疗时的血液和气道，以更好地评估这些标准治疗的效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. COPD stands for Chronic Obstructive Pulmonary Disease. COPD is a term that refers mainly to two closely related respiratory disorders that gradually take a person's breath away: chronic bronchitis and/or emphysema associated with airflow obstruction. The primary symptom of COPD is shortness of breath accompanied by a cough or wheezing. There is no cure for COPD, only treatment to ease the symptoms of this disease. However, researchers are not clear how this disease occurs. The easiest way to obtain researchable information is to take a broncoalveolar lavage (BAL) and or endobronchial biopsy sample since they contain cells, proteins (combination of amino acids that make-up cells) and other factors. A BAL sample is fluid produced by the lungs mixed with sterile (free from germs that cause infection) salt water. An endobronchial biopsy sample is a piece of lung tissue the size of a breadcrumb taken from the larger, closer air passages. The purpose of this study is to evaluate the blood and airway of subjects with mild to moderate COPD while undergoing standard treatment to better assess how these standard therapies work.