INFLUENCE OF L-ARGININE ON AUTONOMIC-CARDIOVASCULAR FUNCTION IN AGING HUMANS

L-精氨酸对老年人自主心血管功能的影响

• 批准号: 7377873
• 负责人: PHILLIP GATES
• 金额: $ 0.37万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377873
• 关键词: INFLUENCE; ARGININE; AUTONOMIC; CARDIOVASCULAR; FUNCTION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A number of adverse changes occur to the cardiovascular (heart and blood vessels) and nervous systems with advancing age. The mechanisms (biological reasons) underlying these changes are unknown. However, we do know that: a) decreased tonic nitric oxide (NO) bioavailability can cause similar adverse changes that can be observed in patients with certain cardiovascular diseases; and b) tonic NO bioavailability decreases with advancing age. In addition, we also know that regular aerobic exercise is associated with improved cardiovascular and nervous system function as well as greater tonic NO bioavailability. Accordingly, the proposed research will test the hypothesis that the adverse changes in cardiovascular and nervous system funcion with aging is due, in part by, decreased tonic NO bioavailability, whereas the more optimal function associated with regular exercise is due to greater NO production. This will be determined by administering the precursor to NO (L-Arginine) in young and older sedentary men and women, and in endurance exercise trained older adults while measuring cardiovascular and nervous system functions before and after this administration.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。随着年龄的增长，心血管（心脏和血管）和神经系统会发生一些不利的变化。这些变化背后的机制（生物学原因）尚不清楚。然而，我们知道：a）降低的紧张性一氧化氮（NO）生物利用度可引起在患有某些心血管疾病的患者中可观察到的类似不利变化;和B）紧张性NO生物利用度随年龄增长而降低。此外，我们还知道，有规律的有氧运动与改善心血管和神经系统功能以及更大的滋补NO生物利用度有关。因此，拟议的研究将测试这一假设，即随着年龄的增长，心血管和神经系统功能的不利变化部分是由于紧张性NO生物利用度降低，而与定期运动相关的更佳功能是由于NO产生更多。这将通过在年轻和老年久坐的男性和女性中施用NO前体（L-精氨酸）以及在耐力运动训练的老年人中施用NO前体（L-精氨酸）来确定，同时测量施用前后的心血管和神经系统功能。