THE EFFECTS OF CALORIC RESTRICTION ON THE HYPERMETABOLISM OF HIV LIPODYSTROPHY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。HIV脂肪营养不良是一种最近被描述的疾病，在这种疾病中，HIV感染患者的脂肪组织会出现各种问题。这包括皮下脂肪的减少和腹部深层脂肪的增加。脂肪组织器官的这些变化通常伴随着胰岛素抵抗，这可能导致糖尿病，以及血脂的变化，包括高胆固醇和甘油三酯水平。我们发现HIV脂肪营养不良患者的基础代谢率也有所增加。换句话说，他们在休息时消耗的卡路里比没有脂肪营养不良的hiv感染者和健康人要多。这种加速的代谢率可能是一个问题，在疾病发作时，食欲通常会下降。因此，患有HIV脂肪营养不良的患者在这段时间可能面临严重体重减轻的风险。目前尚不清楚为什么HIV脂肪营养不良患者会出现高代谢。一种可能是它们失去了皮下脂肪，没有足够的储存能力。因此，我们计划对艾滋病毒脂肪营养不良患者进行短期（3天）卡路里限制饮食，并确定基础代谢率是否显着下降或恢复正常。如果是这样的话，这就意味着患有这种综合症的患者能够增加能量消耗，以应对超过他们储存卡路里能力的热量摄入。这项研究将进一步了解体重调节的一般。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV lipodystrophy is a recently described disorder in which patients with HIV infection develop a variety of problems with their adipose tissue. This includes a loss of subcutaneous fat and an increase in deep abdominal fat. These changes in the adipose tissue organ are usually accompanied by insulin resistance, which can lead to diabetes mellitus, and changes in blood lipids including high cholesterol and triglyceride levels. We have found that patients with HIV lipodystrophy also have increased basal metabolic rates. In other words, they expend more calories at rest than do HIV-infected patients without lipodystrophy and healthy individuals. This accelerated metabolic rate could be a problem in times of intercurrent illness when the appetite typically falls. Patients with HIV lipodystrophy may therefore be at risk for severe weight loss in these times. It is unclear why patients with HIV lipodystrophy are hypermetabolic. One possibility is that they do not have enough storage capacity because they have lost their subcutaneous fat. We therefore plan to put patients with HIV lipodystrophy on a short-term (3 days)calorie-restricted diet and determine if basal metabolic rate falls significantly or normalizes. If this is the case, it would imply that patients with this syndrome are able to increase energy expenditure in response to caloric intake that exceeds their ability to store the calories. This research would further understanding of weight regulation in general.