THE EFFECTS OF CALORIC RESTRICTION ON THE HYPERMETABOLISM OF HIV LIPODYSTROPHY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。HIV脂肪营养不良是一种最近描述的疾病，其中HIV感染患者的脂肪组织出现各种问题。这包括皮下脂肪的减少和腹部深层脂肪的增加。脂肪组织器官的这些变化通常伴随着胰岛素抵抗，这可能导致糖尿病，以及血脂的变化，包括高胆固醇和甘油三酯水平。我们发现HIV脂肪代谢障碍患者的基础代谢率也有所增加。换句话说，他们在休息时消耗的卡路里比没有脂肪代谢障碍的艾滋病毒感染者和健康人更多。这种加速的代谢率可能是一个问题时，并发疾病时，食欲通常福尔斯。因此，HIV脂肪营养不良患者在这些时间可能有严重体重减轻的风险。目前尚不清楚为什么HIV脂肪代谢障碍患者是高代谢的。一种可能是他们没有足够的储存能力，因为他们失去了皮下脂肪。因此，我们计划让HIV脂肪代谢障碍患者接受短期（3天）热量限制饮食，并确定基础代谢率是否显著福尔斯或正常化。如果是这种情况，这意味着患有这种综合征的患者能够增加能量消耗，以应对超过其储存卡路里能力的热量摄入。这项研究将进一步了解一般的体重调节。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV lipodystrophy is a recently described disorder in which patients with HIV infection develop a variety of problems with their adipose tissue. This includes a loss of subcutaneous fat and an increase in deep abdominal fat. These changes in the adipose tissue organ are usually accompanied by insulin resistance, which can lead to diabetes mellitus, and changes in blood lipids including high cholesterol and triglyceride levels. We have found that patients with HIV lipodystrophy also have increased basal metabolic rates. In other words, they expend more calories at rest than do HIV-infected patients without lipodystrophy and healthy individuals. This accelerated metabolic rate could be a problem in times of intercurrent illness when the appetite typically falls. Patients with HIV lipodystrophy may therefore be at risk for severe weight loss in these times. It is unclear why patients with HIV lipodystrophy are hypermetabolic. One possibility is that they do not have enough storage capacity because they have lost their subcutaneous fat. We therefore plan to put patients with HIV lipodystrophy on a short-term (3 days)calorie-restricted diet and determine if basal metabolic rate falls significantly or normalizes. If this is the case, it would imply that patients with this syndrome are able to increase energy expenditure in response to caloric intake that exceeds their ability to store the calories. This research would further understanding of weight regulation in general.