NEUROMUSCULAR CONDITIONING THERAPY FOR DYSSYNERGIC DEFECATION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这个多学科的提案将研究标准和创新的替代治疗方法对由于排便失调引起的便秘患者的疗效。便秘影响着至少400万美国人，主要是女性和老年人。它的特征很差，治疗也不充分。至少50%的慢性便秘患者表现出排便不协调或不协同。在这些患者中，生物反馈疗法可以改善症状。这项建议涉及三个广泛的目标。第一个是确定生物反馈疗法是否有效管理排便障碍，第二个是调查家庭培训的疗效，第三个是调查心理社会功能和生活质量以及治疗对这些参数的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This multidisciplinary proposal will investigate the efficacy of both standard and innovative, alternative treatments for patients with constipation due to dyssynergic defecation. Constipation affects at least four million Americans, predominantly women and the elderly. It is poorly characterized and inadequately treated. At least 50% of patients with chronic constipation exhibit uncoordinated or dyssynergic defecation. In these patients, biofeedback therapy may improve symptoms. This proposal addresses three broad objectives. The first is to determine if biofeedback therapy is effective in the management of dyssynergic defecation, the second is to investigate the efficacy of home-training and the third is to investigate the psychosocial function and quality of life and the impact of treatment on these parameters.