DOES EXERCISE-INDUCED HYPERTENSION IN WEIGHT LIFTING REDUCE VASCULAR REACTIVITY?

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在这项研究中，我们通过测量腿压运动诱发高血压前后肱动脉血流介导的血管舒张（FMD）来研究短暂高血压对血管内皮的影响。肱动脉FMD是一种动脉内皮功能的无创测量方法，与冠状动脉内皮功能相关，在所有已知的动脉粥样硬化危险状态下都是钝化的。如果重量训练引起的短暂高血压使FMD变钝，这将进一步证明短暂的高血压发作可能代表了一种以前未被认识到的动脉粥样硬化危险因素。10名年龄在22 ~ 40岁，无已知心血管危险因素，并定期进行举重训练的受试者（9男1女），平均30.7岁。在这些训练有素的运动员中，我们没有看到运动引起的高血压后FMD的减少。未来的计划包括对非运动员进行测试，以确定这是否代表了一种仅在经常暴露于短暂高血压发作的运动员中看到的适应性，还是对人类短暂高血压影响的普遍抵抗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study we are examining the effect of brief hypertension on the vascular endothelium by measuring flow-mediated vasodilation (FMD) of the brachial artery before and after leg press exercise induced hypertension. Brachial artery FMD is a noninvasive measure of arterial endothelial function that correlates with coronary artery endothelial function and is blunted in all known atherosclerotic risk states. If weight training induced brief hypertension blunts FMD, it would add to the evidence that brief episodes of hypertension may represent a previously unrecognized risk factor for atherosclerosis. 10 subjects (9 men and 1 woman) aged 22 to 40 years (mean 30.7) without known cardiovascular risk factors who regularly engaged in weight training have participated in this study. In these well trained athletes, we have not seen a reduction in FMD after exercise induced hypertension. Future plans include testing non-athletes to determine if this represents an adaptation seen only in athletes who are regularly exposed to brief episodes of hypertension, or a general resistance to the effect of brief hypertension in humans.