DOES EXERCISE-INDUCED HYPERTENSION IN WEIGHT LIFTING REDUCE VASCULAR REACTIVITY?

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。在这项研究中，我们正在研究的影响，短暂的高血压对血管内皮细胞通过测量血流介导的血管舒张（FMD）的肱动脉之前和之后的腿部压力运动诱发的高血压。肱动脉FMD是一种与冠状动脉内皮功能相关的动脉内皮功能的非侵入性测量方法，在所有已知的动脉粥样硬化风险状态下都是钝性的。如果举重训练引起的短暂高血压可以减弱FMD，这将进一步证明短暂的高血压可能是动脉粥样硬化的一个以前未被认识的危险因素。10名受试者（9名男性和1名女性）参加了这项研究，年龄22至40岁（平均30.7岁），无已知的心血管危险因素，定期参加重量训练。在这些训练有素的运动员中，我们没有看到运动诱发高血压后FMD减少。未来的计划包括对非运动员进行测试，以确定这是否代表了一种适应性，这种适应性只存在于经常暴露于短暂高血压发作的运动员中，或者是对人类短暂高血压影响的普遍抵抗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study we are examining the effect of brief hypertension on the vascular endothelium by measuring flow-mediated vasodilation (FMD) of the brachial artery before and after leg press exercise induced hypertension. Brachial artery FMD is a noninvasive measure of arterial endothelial function that correlates with coronary artery endothelial function and is blunted in all known atherosclerotic risk states. If weight training induced brief hypertension blunts FMD, it would add to the evidence that brief episodes of hypertension may represent a previously unrecognized risk factor for atherosclerosis. 10 subjects (9 men and 1 woman) aged 22 to 40 years (mean 30.7) without known cardiovascular risk factors who regularly engaged in weight training have participated in this study. In these well trained athletes, we have not seen a reduction in FMD after exercise induced hypertension. Future plans include testing non-athletes to determine if this represents an adaptation seen only in athletes who are regularly exposed to brief episodes of hypertension, or a general resistance to the effect of brief hypertension in humans.