DOES ENDURANCE EXERCISE PROTECT AGAINST ENDOTHELIAL DYSFUNCTION?

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究旨在探讨急性运动性高血压对运动员血管内皮功能的影响。多达132名年龄在18岁至40岁之间的男性运动员将主要从当地健身俱乐部招募。这些人将包括一组进行或不进行上体举重的跑步者或举重运动员(n=32-33)，以及一组久坐不动的个人。女性没有被包括在内，因为这种保护作用在男性身上得到了证明，但在女性身上没有。研究前评估将包括血脂和完整的血细胞计数(储存额外的血液以备将来可能测定同型半胱氨酸或C反应蛋白水平)，以及用于常规尿液分析和类固醇筛查的尿样，大体人体测量，以及通过血流介导的血管扩张测量臂部内皮功能。然后，受试者将去健身房进行特定的举重养生法，在此期间监测血压。在完成例行锻炼的一小时内，受试者将接受内皮功能的重新评估，并抽取第二份血样。GCRC空间被要求用于考察访问。要求护理人员协助抽血、采集生命体征和注射硝酸甘油(如有需要)。生物统计学将协助分析收集的数据，而核心实验室将确定血清脂质。CBC和类固醇测试也需要GCRC支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study aims to determine the effect of acute exertionally-induced hypertension on endothelial function in athletes. Up to 132 male athletes, ages 18-40, will be recruited primarily from local health clubs. These will include groups of runners or weight lifters who do or do not perform upper body weight lifting (n = 32-33), and a group of sedentary individuals. Women are not included, as this protective effect has been demonstrated in men but not women. A pre-study evaluation will include serum lipids and a complete blood count (with additional blood being stored for possible future determinations of homocysteine or CRP levels), as well as a urine sample for routine urinalysis and steroids screening, determination of gross anthropometrics, and measurement of brachial endothelial function by flow-mediated vasodilation. The subject will then go to the gym to perform a specific weight lifting regimen, during which blood pressures are monitored. Within one hour of completing the exercise routine, subjects will be reassessed for endothelial function, and a second blood sample is drawn. GCRC space is requested for study visits. Nursing assistance is requested for blood draws, vital sign collections, and administration of nitroglycerin if ordered. Biostatistics will assist with the analysis of collected data, while the Core Laboratory will determine serum lipids. GCRC support is also requested for CBC and steroid testing.