DOES ENDURANCE EXERCISE PROTECT AGAINST ENDOTHELIAL DYSFUNCTION?

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究旨在确定急性运动性高血压对运动员内皮功能的影响。最多132名年龄在18-40岁之间的男性运动员将主要从当地的健身俱乐部招募。这些将包括进行或不进行上半身举重的跑步者或举重者组（n = 32-33），以及一组久坐的个人。妇女不包括在内，因为这种保护作用在男子身上得到证明，但在妇女身上没有。研究前评估将包括血脂和全血细胞计数（储存额外血液用于将来可能测定同型半胱氨酸或CRP水平），以及用于常规尿分析和类固醇筛查的尿液样本，测定大体人体测量学，并通过血流介导的血管舒张测量肱动脉内皮功能。然后，受试者将前往健身房进行特定的举重方案，在此期间监测血压。在完成常规运动后1小时内，将重新评估受试者的内皮功能，并采集第二份血样。研究访视需要GCRC空间。抽血、生命体征采集和硝酸甘油给药（如果需要）需要护理协助。生物统计学将协助分析收集的数据，而核心实验室将测定血脂。还要求GCRC支持CBC和类固醇检测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study aims to determine the effect of acute exertionally-induced hypertension on endothelial function in athletes. Up to 132 male athletes, ages 18-40, will be recruited primarily from local health clubs. These will include groups of runners or weight lifters who do or do not perform upper body weight lifting (n = 32-33), and a group of sedentary individuals. Women are not included, as this protective effect has been demonstrated in men but not women. A pre-study evaluation will include serum lipids and a complete blood count (with additional blood being stored for possible future determinations of homocysteine or CRP levels), as well as a urine sample for routine urinalysis and steroids screening, determination of gross anthropometrics, and measurement of brachial endothelial function by flow-mediated vasodilation. The subject will then go to the gym to perform a specific weight lifting regimen, during which blood pressures are monitored. Within one hour of completing the exercise routine, subjects will be reassessed for endothelial function, and a second blood sample is drawn. GCRC space is requested for study visits. Nursing assistance is requested for blood draws, vital sign collections, and administration of nitroglycerin if ordered. Biostatistics will assist with the analysis of collected data, while the Core Laboratory will determine serum lipids. GCRC support is also requested for CBC and steroid testing.