EFFECT OF DELTA9 TETRAHYDROCANNABINOL ON CEREBRAL ACTIVITY MEASURED BY MRI

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目要检验的总体假设是，THC会在人类大脑的活动中产生特征性的变化，无论是在休息时还是在认知和知觉运动任务的执行过程中，这些任务都可以通过功能磁共振成像(FMRI)测量血流和神经元活动来测量。我们进一步提出，THC和大麻对人类的行为和生理影响是由于急性给药后大脑区域参与的独特模式，并且两者在时间和幅度上是相关的。我们已经完成了以下方面的研究：我们已经确定了3种剂量的THC对大脑活动的影响，其中包括几个脑区活动的剂量依赖变化的发现，以及THC的给药通过一系列认知和运动任务降低了大脑的激活。此外，我们还实时测量了THC对接受扫描的受试者的主观影响，并用它们来研究与之相关的大脑活动的变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall hypothesis to be tested by this project is that THC produces characteristic changes in the activity of the human brain, both at rest and during the performance of cognitive and perceptual-motor tasks that are measurable using functional magnetic resonance imaging (fMRI) measures of blood flow and neuronal activity. We further propose that the behavioral and physiological effects of THC and marijuana in humans are due to a unique pattern of brain regions engaged following acute drug administration, and that the two will be related in time and magnitude. We have completed studies in the following areas: We have determined the effects of 3 doses of THC on brain activity, which included findings of a dose-dependent changes in activity in several brain regions and that THC administration decreased brain activation by a series of cognitive and motor tasks. In addition we have measured in real-time, the subjective effects of THC in subjects undergoing scanning and used them to investigate changes in brain activity associated with them.