EFFECTS OF SMOKING AND CESSATION ON BRAIN ACTIVITY

吸烟和戒烟对大脑活动的影响

• 批准号: 7375112
• 负责人: ALAN S BLOOM
• 金额: $ 2.38万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375112
• 关键词: EFFECTS; SMOKING; CESSATION; BRAIN; ACTIVITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to assess alterations in cerebral activation patterns resulting from cigarette smoking and withdrawal from chronic nicotine self-administration. Functional MRI will be used to measure the ability of cognitive and motor tasks to increase cerebral activity dependent upon smoking status, withdrawal time, and intensity of withdrawal symptoms. 110 chronic cigarette smokers and 40 age- and education-matched controls (18-50 years) will be screened by telephone, then visit the GCRC for informed consent, history, and physical exam, and structured interview and questionnaires to permit scoring for nicotine dependence. Exhaled CO will be measured. Subjects will then undergo whole body structural and functional MRI scanning (3T), during which task activation and performance testing will be performed. Subjects in SA 1 (differences between chronic smokers and nonsmokers in task activation) will be scanned once, 5 times in SA 2 (altered task activation with cessation), and 4 times in SA 3. Subjects in SA 3 (role of nicotine in the withdrawal syndrome) will receive IV and/or patch nicotine replacement. GCRC nursing support is requested to obtain and process blood and urine samples, assist with consenting, and place IV lines. GCRC nurses are also needed to assist with drug run-up procedures on the IV nicotine subjects. GCRC Biostatistics is needed for data analysis, the fMRI Core for scanning analysis. GCRC support is also requested for scanning fees, CBC and AST testing, and urine drug triage, pregnancy testing, and cotidine testing.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是评估吸烟和慢性尼古丁自我给药戒断导致的大脑激活模式的改变。功能性MRI将用于测量认知和运动任务增加大脑活动的能力，这取决于吸烟状态、戒断时间和戒断症状的强度。将通过电话筛选110名长期吸烟者和40名年龄和教育程度匹配的对照（18-50岁），然后访问GCRC以获得知情同意、病史和体格检查，并进行结构化访谈和问卷调查，以进行尼古丁依赖评分。将测量呼出的CO。然后，受试者将接受全身结构和功能MRI扫描（3 T），在此期间将进行任务激活和性能测试。SA 1中的受试者（慢性吸烟者和非吸烟者在任务激活方面的差异）将接受一次扫描，SA 2中的受试者将接受5次扫描（停止后任务激活改变），SA 3中的受试者将接受4次扫描。SA 3（尼古丁在戒断综合征中的作用）的受试者将接受IV和/或贴片尼古丁替代治疗。需要GCRC护理支持以获取和处理血液和尿液样本，协助签署同意书，并放置IV管路。还需要GCRC护士协助IV尼古丁受试者的药物运行程序。GCRC Biostatistics用于数据分析，fMRI Core用于扫描分析。GCRC的支持也要求扫描费，CBC和AST测试，尿液药物分诊，妊娠测试和考替丁测试。