EFFECTS OF SMOKING AND CESSATION ON BRAIN ACTIVITY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是评估吸烟和慢性尼古丁自我服用戒断对大脑激活模式的影响。功能性MRI将用于测量认知和运动任务增加大脑活动的能力，这取决于吸烟状况、戒断时间和戒断症状的强度。110名慢性吸烟者和40名年龄和教育程度相匹配的对照组（18-50岁）将通过电话筛选，然后访问GCRC进行知情同意、病史和体格检查，并进行结构化访谈和问卷调查，以便对尼古丁依赖进行评分。将测量呼出的一氧化碳。然后，受试者将接受全身结构和功能MRI扫描（3T），在此期间将进行任务激活和性能测试。sa1组（长期吸烟者和非吸烟者在任务激活上的差异）的受试者将被扫描一次，sa2组（戒烟后改变任务激活）的受试者将被扫描5次，sa3组被扫描4次。SA 3组（尼古丁在戒断综合征中的作用）的受试者将接受静脉注射和/或贴片尼古丁替代。要求GCRC提供护理支持，以获取和处理血液和尿液样本，协助同意，并放置静脉滴注管。GCRC护士也需要协助静脉注射尼古丁受试者的药物准备程序。数据分析需要GCRC生物统计学，扫描分析需要fMRI Core。还要求GCRC支持扫描费、全血细胞计数和谷草转氨酶检测、尿液药物分类、妊娠检测和可替丁检测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to assess alterations in cerebral activation patterns resulting from cigarette smoking and withdrawal from chronic nicotine self-administration. Functional MRI will be used to measure the ability of cognitive and motor tasks to increase cerebral activity dependent upon smoking status, withdrawal time, and intensity of withdrawal symptoms. 110 chronic cigarette smokers and 40 age- and education-matched controls (18-50 years) will be screened by telephone, then visit the GCRC for informed consent, history, and physical exam, and structured interview and questionnaires to permit scoring for nicotine dependence. Exhaled CO will be measured. Subjects will then undergo whole body structural and functional MRI scanning (3T), during which task activation and performance testing will be performed. Subjects in SA 1 (differences between chronic smokers and nonsmokers in task activation) will be scanned once, 5 times in SA 2 (altered task activation with cessation), and 4 times in SA 3. Subjects in SA 3 (role of nicotine in the withdrawal syndrome) will receive IV and/or patch nicotine replacement. GCRC nursing support is requested to obtain and process blood and urine samples, assist with consenting, and place IV lines. GCRC nurses are also needed to assist with drug run-up procedures on the IV nicotine subjects. GCRC Biostatistics is needed for data analysis, the fMRI Core for scanning analysis. GCRC support is also requested for scanning fees, CBC and AST testing, and urine drug triage, pregnancy testing, and cotidine testing.