EFFECT OF OOPHORECTOMY IN POSTMENOPAUSAL WOMEN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。30%的女性在进入更年期时接受了卵巢切除术；这些手术大多是“预防性的”或“偶然的”。然而，现在越来越多的人意识到绝经后卵巢在维持绝经后睾酮(T)水平方面的功能。在性腺功能低下的男性中，T缺乏具有显著的形态计量学和代谢后果，减少肌肉质量、力量、运动耐受性和增加胰岛素抵抗。同样的效果会发生在手术阉割的t细胞缺乏的女性身上吗？为了解决这个问题，本建议概述了绝经后卵巢切除术的形态学、耐力和糖尿病后遗症的横断面检查，并与妇科完整对照组进行比较。我们假设，绝经后的女性，卵巢切除术的历史，随之而来的低T水平，会导致肌肉量减少，脂肪量增加，力量和最大运动耐量（VO2 max）下降，以及胰岛素敏感性降低。如果在这项研究中看到这样的变化，那么就产生了令人信服的初步数据，可以更严格地检查偶然或预防性卵巢切除术的不良后遗症，以及生理性T替代的潜在治疗益处。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Oophorectomy is performed in 30% of women by the time they enter menopause; most of these procedures are "prophylactic" or "incidental". However there is now increasing awareness of the functionality of the postmenopausal ovary in maintaining postmenopausal testosterone (T) levels. In hypogonadal men, T deficiency has significant morphometric and metabolic consequences, decreasing muscle mass, strength, exercise tolerance, and increasing insulin resistance. Do the same effects occur in surgically castrate T-deficient women? In order to address this issue, this proposal outlines a cross-sectional examination of the morphometric, endurance, and diabetogenic sequelae of postmenopausal oophorectomy, compared to a gynecologically intact control group. We hypothesize that in postmenopausal women, a history of oophorectomy, and consequent low T levels, creates a predisposition to decreased muscle mass, increased fat mass, decreased strength and maximal exercise tolerance (VO2 max), as well as decreased insulin sensitivity. If such changes are seen in this study, then compelling preliminary data is generated for a more rigorous examination of the adverse sequelae of incidental or prophylactic oophorectomy, as well as the potential therapeutic benefit of physiologic T replacement.