OMEGA 3 FATTY ACIDS: ANTI-INFLAMMATORY PROPERTIES AND INFLUENCE ON C-REACTIVE PR

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项研究将评估膳食补充欧米茄3脂肪酸（鱼油）是否会减少心血管疾病高风险人群的炎症，而不会增加氧化应激。将招募20名健康但表现出心血管疾病风险因素升高的男性和女性作为参与者。受试者将被随机分配每天接受鱼油或安慰剂胶囊，持续4个月。将在基线、2个月和4个月时测定氧化应激和炎症过程的指标。 为了完成该项目，将使用GCRC进行筛选和终点测量访视。需要GCRC GC/MS实验室测定8-iso PGF 2a（氧化应激的一种测量方法）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will be assessing whether dietary supplementation with omega 3 fatty acid (fish oil) will reduce inflammation in individuals with a high risk profile for cardiovascular disease without an elevation on oxidative stress. Twenty men and women who are healthy but exhibit elevated risk factors for cardiovascular disease will be recruited as participants. Subjects will be randomly assigned to receive fish oil or placebo capsules daily for a 4-month period. Measures of oxidative stress and inflammatory processes will be determined at baseline, 2 and 4 months. In order to accomplish this project, the GCRC will be utilized for screening and endpoint mesurement visits. The GCRC GC/MS laboratory will be required for determination of 8-iso PGF2a, a measure of oxidative stress.