OMEGA 3 FATTY ACIDS: ANTI-INFLAMMATORY PROPERTIES AND INFLUENCE ON C-REACTIVE PR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将评估在饮食中补充omega 3脂肪酸(鱼油)是否会减少心血管疾病高危人群的炎症，而不会增加氧化应激。20名健康但心血管疾病风险因素升高的男性和女性将被招募为参与者。受试者将被随机分配到每天服用鱼油或安慰剂胶囊，为期4个月。氧化应激和炎症过程的测量将在基线、2个月和4个月确定。 为了完成这一项目，将利用GCRC进行筛查和终点测量访问。GCRC GC/MS实验室将需要测定8-iso PGF2a，这是一种衡量氧化应激的指标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will be assessing whether dietary supplementation with omega 3 fatty acid (fish oil) will reduce inflammation in individuals with a high risk profile for cardiovascular disease without an elevation on oxidative stress. Twenty men and women who are healthy but exhibit elevated risk factors for cardiovascular disease will be recruited as participants. Subjects will be randomly assigned to receive fish oil or placebo capsules daily for a 4-month period. Measures of oxidative stress and inflammatory processes will be determined at baseline, 2 and 4 months. In order to accomplish this project, the GCRC will be utilized for screening and endpoint mesurement visits. The GCRC GC/MS laboratory will be required for determination of 8-iso PGF2a, a measure of oxidative stress.