EFFECT OF A COX-2 INHIBITOR OR AN ACE INHIBITOR ON T-CELL ACTIVATION IN HIV INFE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定是研究者机构。HIV感染导致慢性炎症状态和免疫系统的进行性损害。持续性炎症的一种表现是持续的T淋巴细胞活化，这可能导致损伤（即，纤维化）和CD 4 T细胞稳态。在这项研究中，我们将研究抗炎剂（塞来昔布）或抗纤维化剂（赖诺普利）对T细胞活化和淋巴结纤维化的影响。GCRC将帮助我们在淋巴结活检前后监测受试者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV infection causes a chronic inflammatory state and progressive damage of the immune system. One manifestation of the ongoing inflammation is continuous T lymphocyte activation, which may contribute to damage (i.e., fibrosis) of the lymphatic system and CD4T cell homeostasis. In this study we will investigate the effect of an anti-inflammatory agent (celecoxib) or an anti-fibrotic agent (lisinopril) on T-cell activation and lymph node fibrosis. The GCRC will help us to monitor subjects before and after a lymph node biopsy is performed.