EFFECT OF A COX-2 INHIBITOR OR AN ACE INHIBITOR ON T-CELL ACTIVATION IN HIV INFE

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV infection causes a chronic inflammatory state and progressive damage of the immune system. One manifestation of the ongoing inflammation is continuous T lymphocyte activation, which may contribute to damage (i.e., fibrosis) of the lymphatic system and CD4T cell homeostasis. In this study we will investigate the effect of an anti-inflammatory agent (celecoxib) or an anti-fibrotic agent (lisinopril) on T-cell activation and lymph node fibrosis. The GCRC will help us to monitor subjects before and after a lymph node biopsy is performed.