METABOLIC EFFECTS OF ALCOHOL IN THE FORM OF WINE IN PERSONS WITH TYPE 2 DIABETES

葡萄酒中的酒精对 2 型糖尿病患者的代谢影响

• 批准号: 7375956
• 负责人: JOHN P BANTLE
• 金额: $ 5.92万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375956
• 关键词: METABOLIC; EFFECTS; ALCOHOL; FORM; WINE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The use of alcohol in moderation has been associated with reduced mortality rates, reduced risk of cardiovascular disease and reduced risk for type 2 diabetes mellitus. However, the effects of alcohol in persons with type 2 diabetes mellitus have not been clearly defined. Although alcohol does not appear to raise blood glucose, its potential to lower blood glucose needs further study. Moreover, the possibility of alcohol induced hypoglycemia remains a safety concern. Finally, little is known about the effects of alcohol on plasma lipids in people with diabetes. To address these issues, two substudies are proposed. The first substudy will examine the accute effects of alcohol in the form of wine at supper on postprandial and nocturnal plasma glucose levels. The hypothesis to be tested is that the use of alcohol in the form of wine with the evening meal will result in lower fasting plasma glucose the next morning. The second substudy will examine the effects of alcohol in the form of wine consumed regularly for one month on plasma lipids. The hypothesis to be tested is that the chronic use of alcohol in moderation in the form of wine will have beneficial effects on plasma lipids.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。适量饮酒与降低死亡率、降低心血管疾病风险和降低2型糖尿病风险有关。然而，酒精对2型糖尿病患者的影响尚未明确界定。虽然酒精似乎不会升高血糖，但其降低血糖的潜力需要进一步研究。此外，酒精诱导低血糖的可能性仍然是一个安全性问题。最后，酒精对糖尿病患者血脂的影响知之甚少。为了解决这些问题，提出了两个子研究。第一个子研究将检查晚餐时饮酒对餐后和夜间血糖水平的影响。待检验的假设是，晚餐时使用葡萄酒形式的酒精将导致第二天早上空腹血糖降低。第二个子研究将检查以葡萄酒形式定期饮用一个月对血脂的影响。有待检验的假设是，长期适量饮酒（以葡萄酒的形式）将对血脂产生有益影响。