ASPERGILLLUS ANGIONVASION AND DISSEMINATION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research project is to study the interactions of the fungus, Aspergillus Fumigatus, with endothelial cells. Our hypothesis is that the interactions of A. Fumigatus with endothelial cells during the process of angioninvasion are central to the pathogenesis of invasive Aspergillosis. For the proposed studies, the endothelial cells will be harvested from the veins within human umbilical cords and grown in tissue culture.