PATHOGENESIS OF PRIMARY HIV INFECTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是为了更好地确定原发(急性)艾滋病毒感染的自然历史。新感染艾滋病毒的患者经常发展为急性单核细胞增多症样疾病。已经证明，在这种急性疾病发生时，这些人中的许多人的血液中都有高水平的病毒。将广泛跟踪患者的免疫系统变化和病毒载量的变化。患者招募正在进行中，GCRC实验室进行实验室研究的淋巴细胞分离。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to better define the natural history of primary (acute) HIV infection. Patients who are newly infected with HIV frequently develop an acute mononucleosis-like illness. It has been demonstrated that many of these people have high levels of virus in their blood at the time of this acute illness. Patients will be followed extensively for changes in the immune system and for changes in viral load. Patient recruitment is ongoing, and isolation of lymphocytes for laboratory investigation is performed by the GCRC laboratory.