A LONGITUDINAL STUDY OF CEREBRAL AND NEUROCOGNITIVE FUNCTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将试图更多地了解艾滋病毒对大脑的生理和精神影响，并确定谁可能面临与大脑相关的困难的更高风险。这项研究将通过一种名为磁共振波谱的想象测试来观察不同大脑化学物质的数量和不同大脑区域的大小。这项测试的结果将与在这项研究期间完成的神经学和神经心理学测试进行比较。 已登记参加加州神经艾滋病组织网络研究的符合条件的受试者将被问及是否愿意参与这项研究。如果愿意，他们将只执行MRS。为CNTN研究收集的数据将用于与MRS进行比较。 将进行筛查访问，在此期间将记录他们的药物和病史，并将抽取一汤匙血液进行常规实验室检查。女性将接受怀孕测试，如果怀孕，将不参加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will try to learn more about physical and mental effects of HIV on the brain and determine who may be at a higher risk of difficulties related to the brain. The study will observe the amount of different brain chemicals, and the size of different brain regions by doing an imagining test called magnetic resonance spectroscopy. Results from this test will be compared to neurological and neuropsychological tests completed during this study. Eligible subjects already enrolled in the California NeuroAIDS Tissue Network study will be asked if they are willing to participate in this study. If willing, they will have MRS only performed. The data that is being collected for the CNTN study will be used to compare with the MRS. A screening visit will be done, during which their medication and medical history will be taken, and one tablespoon of blood will be taken for routine laboratory tests. Women will have a pregnancy test and will not participate if pregnant.