GENETIC DETERMINANTS OF ANKYLOSING SPONDYLITIS SEVERITY: CROSS SECTIONAL STUDY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究将检验强直性脊柱炎患者20年或更长时间的特定遗传标记与长期健康结果之间的关系。这将在一次性研究访问中完成，以评估放射学和功能结果方面的疾病进展。此外，我们还将测试10年或以下强直性脊柱炎患者的特定遗传标记与炎症严重程度之间的关系。这些患者将接受26个月的监测，以评估放射和功能结果方面的疾病进展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will examine associations between specific genetic markers and long-term health outcomes in patients with ankylosing spondylitis of 20 or more years. This will be done in a one time study visit to assess disease progress in terms of radiological and functional outcomes. Additionally, we will test associations between specific genetic markers and the severity of inflammation in patients with ankylosing spondylitis of 10 years or less. These patients will be monitored for 26 months to assess disease progression in terms of radiological and functional outcomes.