INFLAMMATORY MARKERS IN THE STOOL AND SERUM OF PATIENTS WITH ANKYLOSING SPONDYLI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是检测粪便钙保护素作为强直性脊柱炎(AS)患者可能的炎症标志物及其与炎症性肠病(IBD)血清标志物的相关性。研究人群将包括成人作为患者，他们自己或一级亲属没有IBD(IBD)作为病例，以及没有IBD的健康成年志愿者作为对照。病例将从腰椎研究(强直性脊柱炎预后的前瞻性研究)队列中随机选择，并通过电话和邮件招募，志愿者对照将从洛杉矶地区招募。如果受试者同意参与这项研究，他/她将被邮寄一份同意书和粪便样本试剂盒，并被要求将这两项物品带到研究访问中，我们还将回答任何额外的问题，收集一份血清样本，并提供一份自我管理问卷。每个科目只有一次考察访问。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to test fecal calprotectin as a possible inflammatory marker in patients with ankylosing spondylitis (AS) and as a correlate with serum markers for inflammatory bowel disease (IBD). The study population will include adult AS patients, who themselves or a first degree relative do not have (IBD), as cases, and healthy adult volunteers without IBD as controls. Cases will be randomly selected from the PSOAS study (Prospective Study of Outcomes in Ankylosing Spondylitis) cohort and recruited via phone and mail, and volunteer controls will be recruited from the Los Angeles area. If the subject agrees to participate in the study, he/she will be mailed a consent form and stool sample kit, and asked to bring both items to the study visit where we will also answer any additional questions, collect one serum sample, and provide a self-administer questionnaire. There is only one study visit per subject.