INFLAMMATORY MARKERS IN THE STOOL AND SERUM OF PATIENTS WITH ANKYLOSING SPONDYLI

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 本研究的目的是测试粪便钙卫蛋白作为强直性脊柱炎（AS）患者的可能炎症标志物，并与炎症性肠病（IBD）的血清标志物相关。研究人群将包括自身或一级亲属没有IBD的成人AS患者（作为病例）和没有IBD的健康成人志愿者（作为对照）。病例将从PSOAS研究（强直性脊柱炎结局的前瞻性研究）队列中随机选择，并通过电话和邮件招募，志愿者对照将从洛杉矶地区招募。如果受试者同意参加研究，将向其邮寄知情同意书和粪便样本采集盒，并要求其携带这两样物品参加研究访视，我们还将回答任何其他问题，采集一份血清样本，并提供一份自我管理问卷。每例受试者仅进行一次研究访视。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to test fecal calprotectin as a possible inflammatory marker in patients with ankylosing spondylitis (AS) and as a correlate with serum markers for inflammatory bowel disease (IBD). The study population will include adult AS patients, who themselves or a first degree relative do not have (IBD), as cases, and healthy adult volunteers without IBD as controls. Cases will be randomly selected from the PSOAS study (Prospective Study of Outcomes in Ankylosing Spondylitis) cohort and recruited via phone and mail, and volunteer controls will be recruited from the Los Angeles area. If the subject agrees to participate in the study, he/she will be mailed a consent form and stool sample kit, and asked to bring both items to the study visit where we will also answer any additional questions, collect one serum sample, and provide a self-administer questionnaire. There is only one study visit per subject.