ASSESSMENT AND DETERMINATION OF BIOMARKERS OF INFLAMMATION IN URINE SAMPLES

尿液样本中炎症生物标志物的评估和测定

基本信息

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to assess possible biomarkers of inflammation in human urine. This study will provide information on the feasibility in determining the inflammation status of individuals using urine samples, which is important in accurately measuring nutritional status. Current methods of measuring inflammation are based on the determination of acute phase proteins in plasma or serum, which involve obtaining blood samples. However, obtaining a blood sample is an invasive procedure that requires the expertise of a trained phlebotomist. Nonetheless, phlebotomists sometimes may fail in accessing a vein, or blood volumes are sometimes insufficient for analysis of various analytes. Additionally, some individuals may be reluctant to participate because providing a blood sample, capillary or venous, is not culturally acceptable. This will be a prospective study of patients with acute respiratory infections (ARI) diagnosed, treated, and enrolled at the University Health Services, Ritenour Building. Enrolled Participants will be asked to provide blood and urine samples immediately upon their diagnose of IRA; these samples will be obtained at the University Health Services, Ritenour Building. Then they will come to the GCRC to provide blood and urine samples 7 and 14 days later.
本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者(PI)可能已经从另一个NIH来源获得了主要资金,因此可以在其他CRISP条目中表示。列出的机构是中心的,不一定是研究者的机构。本研究的目的是评估人类尿液中可能的炎症生物标志物。该研究将为利用尿液样本确定个体炎症状态的可行性提供信息,这对于准确测量营养状况非常重要。目前测量炎症的方法是基于血浆或血清中急性期蛋白的测定,这需要获得血液样本。然而,获得血液样本是一个侵入性的过程,需要训练有素的抽血师的专业知识。尽管如此,抽血师有时可能无法进入静脉,或者血容量有时不足以分析各种分析物。此外,有些人可能不愿意参与,因为提供血液样本,毛细血管或静脉,是不被文化接受的。这将是一项前瞻性研究,研究对象是在Ritenour大楼大学卫生服务中心诊断、治疗和登记的急性呼吸道感染(ARI)患者。入选的参与者将被要求在诊断出IRA后立即提供血液和尿液样本;这些样本将在大学卫生服务,Ritenour大楼获得。7天后和14天后,他们会来GCRC提供血样和尿样。

项目成果

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FRANCISCO J ROSALES其他文献

FRANCISCO J ROSALES的其他文献

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{{ truncateString('FRANCISCO J ROSALES', 18)}}的其他基金

ASSESSMENT AND DETERMINATION OF BIOMARKERS OF INFLAMMATION IN URINE SAMPLES
尿液样本中炎症生物标志物的评估和测定
  • 批准号:
    7203586
  • 财政年份:
    2005
  • 资助金额:
    $ 1.16万
  • 项目类别:
KINETIC STUDY OF INFLAMMATION-INDUCED HYPORETINEMIA
炎症引起的低蛋白血症的动力学研究
  • 批准号:
    6679389
  • 财政年份:
    2003
  • 资助金额:
    $ 1.16万
  • 项目类别:
A KINETIC STUDY OF INFLAMMATION-INDUCED HYPORETINEMIA
炎症引起的低蛋白血症的动力学研究
  • 批准号:
    6787273
  • 财政年份:
    2003
  • 资助金额:
    $ 1.16万
  • 项目类别:
A KINETIC STUDY OF INFLAMMATION-INDUCED HYPORETINEMIA
炎症引起的低蛋白血症的动力学研究
  • 批准号:
    6887731
  • 财政年份:
    2003
  • 资助金额:
    $ 1.16万
  • 项目类别:
Analysis of Retinol-Binding Protein Transthyretin
视黄醇结合蛋白转甲状腺素蛋白的分析
  • 批准号:
    7044456
  • 财政年份:
    2003
  • 资助金额:
    $ 1.16万
  • 项目类别:
MECHANISM OF INFLAMMATION INDUCED HYPORETINEMIA
炎症引起低蛋白血症的机制
  • 批准号:
    2015762
  • 财政年份:
    1997
  • 资助金额:
    $ 1.16万
  • 项目类别:
MECHANISM OF INFLAMMATION INDUCED HYPORETINEMIA
炎症引起低蛋白血症的机制
  • 批准号:
    2136104
  • 财政年份:
    1996
  • 资助金额:
    $ 1.16万
  • 项目类别:
MECHANISM OF INFLAMMATION INDUCED HYPORETINEMIA
炎症引起低蛋白血症的机制
  • 批准号:
    2136103
  • 财政年份:
    1994
  • 资助金额:
    $ 1.16万
  • 项目类别:

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