ASSESSMENT AND DETERMINATION OF BIOMARKERS OF INFLAMMATION IN URINE SAMPLES

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。本研究的目的是评估人类尿液中可能的炎症生物标志物。这项研究将提供有关使用尿液样本确定个体炎症状态的可行性的信息，这对于准确测量营养状况非常重要。目前测量炎症的方法基于血浆或血清中急性期蛋白的测定，其中涉及获取血液样本。然而，获取血液样本是一种侵入性操作，需要训练有素的抽血医师的专业知识。尽管如此，抽血者有时可能无法进入静脉，或者血量有时不足以分析各种分析物。此外，有些人可能不愿意参与，因为提供毛细血管或静脉血样在文化上是不可接受的。这将是一项针对在 Ritenour 大楼大学健康服务中心诊断、治疗和登记的急性呼吸道感染 (ARI) 患者的前瞻性研究。登记的参与者在诊断出 IRA 后将被要求立即提供血液和尿液样本；这些样本将在大学健康服务中心 Ritenour 大楼获取。然后他们将在7天和14天后到GCRC提供血液和尿液样本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to assess possible biomarkers of inflammation in human urine. This study will provide information on the feasibility in determining the inflammation status of individuals using urine samples, which is important in accurately measuring nutritional status. Current methods of measuring inflammation are based on the determination of acute phase proteins in plasma or serum, which involve obtaining blood samples. However, obtaining a blood sample is an invasive procedure that requires the expertise of a trained phlebotomist. Nonetheless, phlebotomists sometimes may fail in accessing a vein, or blood volumes are sometimes insufficient for analysis of various analytes. Additionally, some individuals may be reluctant to participate because providing a blood sample, capillary or venous, is not culturally acceptable. This will be a prospective study of patients with acute respiratory infections (ARI) diagnosed, treated, and enrolled at the University Health Services, Ritenour Building. Enrolled Participants will be asked to provide blood and urine samples immediately upon their diagnose of IRA; these samples will be obtained at the University Health Services, Ritenour Building. Then they will come to the GCRC to provide blood and urine samples 7 and 14 days later.