NEUROPHYSIOLOGY STUDIES IN SCHIZOPHRENIA AND RELATED DISORDERS

精神分裂症及相关疾病的神经生理学研究

• 批准号: 7376922
• 负责人: GUNVANT K THAKER
• 金额: $ 0.08万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376922
• 关键词: NEUROPHYSIOLOGY; STUDIES; SCHIZOPHRENIA; RELATED; DISORDERS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Wealth of evidence suggests that schizophrenia is a genetic illness and the genotype is expressed as liability to illness. Schizotypal and related personalities and smooth pursuit eye movement (SPEM) abnormalities are highly prevalent in non-ill relatives of schizophrenic patients and mark the genetic liability to schizophrenia. Our proposal is based on the premise that in the presence of the genetic vulnerability, other non-genotypic factors lead to the overt expression of the illness. Non-genotypic factors are likely to be either environmental stress during development or non specific genetic factors critical for normal brain development. The broad goals of the protocol are: (1) Refine methods of examining eye movements in order to define the cognitive and ocular motor processes which mark the genetic liability; (2) Describe clinical and cognitive correlates of eye movement abnormality in vulnerable individuals; (3) Describe putative markers of non-genotypic factors which may have contributed to the development of the illness in the proband; and, (4) Conduct formal genetic linkage analysis using smooth pursuit eye movement abnormality as a phenotype. One of the goals of this study is to examine potential prenatal stress factors that may play a role in the etiology of schizophrenia. We hypothesize that within a family, individuals with and without the genetic liability, have equal probability of being exposed to putative stress factors. Of the genetically vulnerable individuals, those who are exposed to the stress will develop overt illness, whereas vulnerable individuals not exposed to the stress will only carry the phenotypic marker.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。大量的证据表明，精神分裂症是一种遗传性疾病，基因型表现为易患病性。精神分裂症患者的非患病亲属中，分裂型和相关人格以及平滑追踪眼球运动（SPEM）异常非常普遍，标志着精神分裂症的遗传易感性。我们的建议是基于这样一个前提，即在存在遗传脆弱性的情况下，其他非基因型因素会导致疾病的明显表现。非基因型因素可能是发育过程中的环境压力或对正常大脑发育至关重要的非特异性遗传因素。该方案的主要目标是：（1）改进检查眼球运动的方法，以确定标志遗传易感性的认知和眼球运动过程;（2）描述易感个体眼球运动异常的临床和认知相关性;（3）描述可能导致先证者疾病发展的非基因型因素的假定标记;以及，（4）使用平滑追踪眼球运动异常作为表型进行正式的遗传连锁分析。 本研究的目的之一是检查可能在精神分裂症病因学中发挥作用的潜在产前应激因素。我们假设，在一个家庭中，有和没有遗传责任的个人，有相同的概率被暴露于假定的压力因素。在基因脆弱的个体中，那些暴露于压力的人会发展出明显的疾病，而没有暴露于压力的脆弱个体只会携带表型标记。