FAMILIAL SCHIZOPHRENIA AND SPECTRUM PERSONALITY DISORDERS

家族性精神分裂症和谱系人格障碍

• 批准号: 7376950
• 负责人: GUNVANT K THAKER
• 金额: $ 20.75万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376950
• 关键词: FAMILIAL; SCHIZOPHRENIA; SPECTRUM; PERSONALITY; DISORDERS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The current project plans to examine a large number of endophenotypes in a large cohort of families affected by schizophrenia. This will allow us to search for genes associated with each of the independent endophenotypes, and their interactions. We propose to recruit 150 case families (i.e., families with a schizophrenia proband), 150 control families, and 30 control subjects who exhibit schizophrenia specetrum personality symptoms in the absence of a family histrory of schizophrenia. Participants will undergo a number of clinical, electrophysiological, perceptual, and cognitive assessments. These data will be used to identify phenotypes likely to be associated with genetic risk for schizophrenia, and to determine how these phenotypes aggregate in families. Testing procedures require a 10-12 hour time committment and testing will be completed over 2 or more days. Participants will be asked to give a blood sample, which will be stored for future genetic analyses.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。当前的项目计划检查大量受精神分裂症影响的家庭的大量内表型。这将使我们能够寻找与每个独立内表型相关的基因及其相互作用。我们建议招募 150 个病例家庭（即有精神分裂症先证者的家庭）、150 个对照家庭和 30 个在没有精神分裂症家族史的情况下表现出精神分裂症谱系人格症状的对照受试者。参与者将接受一系列临床、电生理、知觉和认知评估。这些数据将用于识别可能与精神分裂症遗传风险相关的表型，并确定这些表型如何在家庭中聚集。测试程序需要 10-12 小时的时间，测试将在 2 天或更长时间内完成。参与者将被要求提供血液样本，该样本将被存储以供将来的基因分析。