FAMILIAL SCHIZOPHRENIA AND SPECTRUM PERSONALITY DISORDERS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目前的项目计划在一个受精神分裂症影响的大家族队列中检查大量的内表型。这将使我们能够寻找与每个独立的内表型相关的基因，以及它们之间的相互作用。我们建议招募150个病例家庭（即，有精神分裂症先证者的家庭）、150个对照家庭和30个在没有精神分裂症家族史的情况下表现出精神分裂症谱系人格症状的对照受试者。参与者将接受一系列临床、电生理、感知和认知评估。这些数据将被用来识别可能与精神分裂症遗传风险相关的表型，并确定这些表型如何在家庭中聚集。测试程序需要10-12小时的时间承诺，测试将在2天或更长时间内完成。参与者将被要求提供血液样本，这些样本将被储存用于未来的遗传分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The current project plans to examine a large number of endophenotypes in a large cohort of families affected by schizophrenia. This will allow us to search for genes associated with each of the independent endophenotypes, and their interactions. We propose to recruit 150 case families (i.e., families with a schizophrenia proband), 150 control families, and 30 control subjects who exhibit schizophrenia specetrum personality symptoms in the absence of a family histrory of schizophrenia. Participants will undergo a number of clinical, electrophysiological, perceptual, and cognitive assessments. These data will be used to identify phenotypes likely to be associated with genetic risk for schizophrenia, and to determine how these phenotypes aggregate in families. Testing procedures require a 10-12 hour time committment and testing will be completed over 2 or more days. Participants will be asked to give a blood sample, which will be stored for future genetic analyses.