GENETICS IN EARLY-ONSET STROKE

早发性中风的遗传学

• 批准号: 7376921
• 负责人: STEVEN J KITTNER
• 金额: $ 16.69万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376921
• 关键词: GENETICS; EARLY; ONSET; STROKE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While the focus of this proposal will be to examine gene-environment interactions related to three polymorhisms associated with vascular disease, it is important to emphasize that the objectives and implications of this project extend beyond this restricted focus. The loong-range objective of this proposal is to establish a unique resource for continued studies of the genetic basis of vascular disease. Specific aims are to: 1. Estimate the prevalence in the population of history of recent infection, PCR evidence of Chlamydia pneumoniae in peripheral blood, behavioral factors, family history, and genetic polymorphisms of the endotoxin receptro (CD 14), platelet glycoprotein receptor IIb/IIIa (GpIIb-IIIa), and nitric oxide synthase (NOS). 2. Determine the relative risk of these factors for ischemic stroke and for ischemic stroke subtypes. 3. Determine the role of recent infection, chronic infection with C. pneumoniae, and behavioral factors (e.g., cigarette smoking, exercise, oral contraceptive use, alcohol intake) in modifying the effect of genotype status on stroke risk.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。虽然本提案的重点将是研究与血管疾病相关的三种多态性相关的基因-环境相互作用，但重要的是要强调，本项目的目标和影响超出了这一局限性。这项提案的长期目标是建立一个独特的资源，继续研究血管疾病的遗传基础。具体目标是：1。估计人群中近期感染史、外周血中肺炎衣原体PCR证据、行为因素、家族史和内毒素受体（CD 14）、血小板糖蛋白受体IIb/IIIa（GpIIb-IIIa）和一氧化氮合酶（NOS）遗传多态性的患病率。2.确定这些因素对缺血性卒中和缺血性卒中亚型的相对危险度。3.确定近期感染、慢性感染与C.肺炎，和行为因素（例如，吸烟、运动、口服避孕药使用、酒精摄入）在改变基因型状态对中风风险的影响中的作用。