GENETICS OF THE EARLY ONSET OF PSYCHIATRIC DISORDERS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的目的是确定基因组内的变异性，这些变异性可能与25岁之前患上成人精神疾病的风险有关。 为此，我们建议从7至25岁的精神病患者和25岁以上的精神病患者中收集DNA，这些患者在25岁之前有记录的疾病发作以及成年一级亲属。 我们建议利用传统的遗传关联策略以及新的遗传方法来识别可能导致早发性精神疾病发展风险的DNA序列。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to identify variability within the genome that may be associated with the risk of developing an adult psychiatric illness prior to the age of 25-years old. To this end, we propose to collect DNA from psychiatric patients between the ages of 7 and 25 years old and from psychiatric patients over 25 years old who have a documented illness onset prior to the age of 25 years old as well as from adult first-degree relatives. We propose to utilize both traditional genetic association strategies as well as novel genetic approaches to identify the DNA sequences that may confer risk for the development of early onset psychiatric illness.