LIFESTYLE AMP; BIOCHEMICAL CHARACTERISTICS OF A CENTRAL OK NAT AMERICAN POP

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们将通过位于俄克拉荷马州肖尼的公民波塔瓦托米国家健康中心招募参与者，调查中部俄克拉荷马州美洲原住民的运动和饮食习惯。我们还将测量与糖尿病、肥胖和代谢综合征的发展相关的各种血液值，每种血液值都是心血管风险的独立预测因子。我们收集的数据将描述该临床人群的特征，确定进一步研究的可行性，并最终用于计划干预性试验，以预防糖尿病，肥胖和代谢综合征的发展。A.在主要为白种人的人群中，强化生活方式改变和二甲双胍已被证明可降低糖尿病的发病率。这种干预措施尚未在美洲原住民人口中进行专门测试。位于俄克拉荷马州肖尼的公民波塔瓦托米民族健康综合体代表了一个相当独特的环境，大约有一万名土著美国人获得医疗保健或一般健身训练。这代表了一个理想的临床人群，在其中测试干预措施，如上述对美洲原住民的干预措施。然而，为了计划干预措施，必须首先测量研究人群目前的运动和饮食习惯以及各种生化标志物的基线水平。 具体目标1：利用位于俄克拉荷马州肖尼的Citizen Potawatomi Nation Health Services Clinic和Firelake健康中心，描述美国原住民的饮食和运动习惯以及心血管风险的选定体格检查和生化预测因子。具体目标2：确定进一步研究的可行性，特别是在招募这一人群方面。具体目标3：制定一个实用和有效的干预措施，以防止肥胖，糖尿病和代谢综合征，可以在未来的临床试验进行测试的建议。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will survey the exercise and eating habits of the central Oklahoma Native American population recruiting participants through the Citizen Potawatomi Nation Health Center in Shawnee, Oklahoma. We will also measure a variety of blood values that are associated with the development of diabetes, obesity, and the metabolic syndrome, each being an independent predictor of cardiovascular risk. The data we collect will characterize this clinical population, determine the feasibility for further study and, ultimately, be used to plan an interventional trial to prevent the development of diabetes, obesity, and the metabolic syndrome. A. Specific Aims Intensive lifestyle modification and metformin have been shown to decrease the incidence of diabetes mellitus in a primarily Caucasian population. Such interventions have not been specifically tested in a Native American population. The Citizen Potawatomi Nation Health Complex in Shawnee, Oklahoma represents a fairly unique setting in which approximately ten-thousand Native Americans access health care or general fitness training. This represents an ideal clinical population in which to test interventions such as those mentioned above on Native Americans. However, in order to plan an intervention, the current exercise and dietary habits of the study population as well the baseline levels of a variety of biochemical markers must first be measured. Specific aim #1: Characterize the dietary and exercise habits and selected physical exam and biochemical predictors of cardiovascular risk in the Native Americans utilizing the Citizen Potawatomi Nation Health Services Clinic and Firelake wellness Center in Shawnee, Oklahoma. Specific aim #2: Establish feasibility of further study, especially in terms of recruitment, of this population. Specific aim #3: Formulate a recommendation for a practical and effective intervention to prevent obesity, diabetes, and the metabolic syndrome that can be tested in a future clinical trial.