LIFESTYLE AMP; BIOCHEMICAL CHARACTERISTICS OF A CENTRAL OK NAT AMERICAN POP

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will survey the exercise and eating habits of the central Oklahoma Native American population recruiting participants through the Citizen Potawatomi Nation Health Center in Shawnee, Oklahoma. We will also measure a variety of blood values that are associated with the development of diabetes, obesity, and the metabolic syndrome, each being an independent predictor of cardiovascular risk. The data we collect will characterize this clinical population, determine the feasibility for further study and, ultimately, be used to plan an interventional trial to prevent the development of diabetes, obesity, and the metabolic syndrome. A. Specific Aims Intensive lifestyle modification and metformin have been shown to decrease the incidence of diabetes mellitus in a primarily Caucasian population. Such interventions have not been specifically tested in a Native American population. The Citizen Potawatomi Nation Health Complex in Shawnee, Oklahoma represents a fairly unique setting in which approximately ten-thousand Native Americans access health care or general fitness training. This represents an ideal clinical population in which to test interventions such as those mentioned above on Native Americans. However, in order to plan an intervention, the current exercise and dietary habits of the study population as well the baseline levels of a variety of biochemical markers must first be measured. Specific aim #1: Characterize the dietary and exercise habits and selected physical exam and biochemical predictors of cardiovascular risk in the Native Americans utilizing the Citizen Potawatomi Nation Health Services Clinic and Firelake wellness Center in Shawnee, Oklahoma. Specific aim #2: Establish feasibility of further study, especially in terms of recruitment, of this population. Specific aim #3: Formulate a recommendation for a practical and effective intervention to prevent obesity, diabetes, and the metabolic syndrome that can be tested in a future clinical trial.