CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。驱动生物学项目1：调节染色单体分离的蛋白水解途径。有丝分裂过程中的染色体复制和分离对所有生命都至关重要。姐妹染色单体的分离被认为是由一种叫做分离酶的半胱氨酸蛋白酶控制的。然而，我们的初步结果表明，至少有一种其他蛋白酶参与其中，即MT1-MMP。我们将研究有丝分裂过程中染色单体分离过程中蛋白水解的协同级联的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 1: A Proteolytic Pathway that Regulates Chromatid Separation. Chromosomal duplication and separation during mitosis is central to all of life. The separation of sister chromatids is thought to be controlled by a cysteine protease, called separase. Yet our preliminary results indicate that at least one other protease is involved, MT1-MMP. We will investigate the hypothesis that a coordinated cascade of proteolysis is involved in chromatid separation during mitosis.