CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。驱动生物学项目1：一种调节染色单体分离的蛋白分解途径。有丝分裂过程中的染色体复制和分离是所有生命的中心。姐妹染色单体的分离被认为是由一种名为分离酶的半胱氨酸蛋白酶控制的。然而，我们的初步结果表明，至少还有另一种蛋白酶参与其中，即MT1-MMP.我们将研究一种假设，即在有丝分裂过程中，染色单体的分离涉及一系列协调的蛋白分解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 1: A Proteolytic Pathway that Regulates Chromatid Separation. Chromosomal duplication and separation during mitosis is central to all of life. The separation of sister chromatids is thought to be controlled by a cysteine protease, called separase. Yet our preliminary results indicate that at least one other protease is involved, MT1-MMP. We will investigate the hypothesis that a coordinated cascade of proteolysis is involved in chromatid separation during mitosis.