CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。驱动生物项目1：调节染色单体分离的蛋白水解途径。 有丝分裂过程中染色体的复制和分离是所有生命的核心。姐妹染色单体的分离被认为是由半胱氨酸蛋白酶控制的，称为分离酶。然而，我们的初步结果表明，至少有一个其他蛋白酶参与，MT 1-MMP。我们将研究有丝分裂过程中染色单体分离涉及蛋白质水解级联反应的假说。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 1: A Proteolytic Pathway that Regulates Chromatid Separation. Chromosomal duplication and separation during mitosis is central to all of life. The separation of sister chromatids is thought to be controlled by a cysteine protease, called separase. Yet our preliminary results indicate that at least one other protease is involved, MT1-MMP. We will investigate the hypothesis that a coordinated cascade of proteolysis is involved in chromatid separation during mitosis.