CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME
CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME
批准号:
7380827
负责人:
Alex Y Strongin
金额:
$7.97万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-08-01 至 2007-07-31
中文摘要
该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者(PI)可能从另一个NIH来源获得主要资金,因此可以在其他CRISP条目中表示。所列机构为中心,不一定是研究者所在机构。驱动生物项目1:调节染色单体分离的蛋白水解途径。 有丝分裂过程中染色体的复制和分离是所有生命的核心。姐妹染色单体的分离被认为是由半胱氨酸蛋白酶控制的,称为分离酶。然而,我们的初步结果表明,至少有一个其他蛋白酶参与,MT 1-MMP。我们将研究有丝分裂过程中染色单体分离涉及蛋白质水解级联反应的假说。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 1: A Proteolytic Pathway that Regulates Chromatid Separation. Chromosomal duplication and separation during mitosis is central to all of life. The separation of sister chromatids is thought to be controlled by a cysteine protease, called separase. Yet our preliminary results indicate that at least one other protease is involved, MT1-MMP. We will investigate the hypothesis that a coordinated cascade of proteolysis is involved in chromatid separation during mitosis.
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(PQ10) Do microbiota alter the epigenetic landscape in human genome
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批准号:9171885
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项目类别:
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资助金额:$25.45万
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财政年份:2016
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负责人:Alex Y Strongin
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依托单位:
Biochemistry of MT1-MMP activation in malignancy
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批准号:8627145
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项目类别:
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资助金额:$37.68万
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财政年份:2011
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负责人:Alex Y Strongin
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依托单位:
Biochemistry of MT1-MMP activation in malignancy
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批准号:8076957
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项目类别:
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资助金额:$38.05万
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财政年份:2011
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负责人:Alex Y Strongin
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依托单位:
Biochemistry of MT1-MMP activation in malignancy
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批准号:8446163
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项目类别:
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资助金额:$36.51万
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财政年份:2011
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负责人:Alex Y Strongin
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依托单位:
Biochemistry of MT1-MMP activation in malignancy
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批准号:8270459
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项目类别:
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资助金额:$38.05万
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财政年份:2011
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负责人:Alex Y Strongin
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依托单位:
Biochemistry of MT1-MMP activation in malignancy
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批准号:8826052
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项目类别:
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资助金额:$38.84万
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财政年份:2011
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负责人:Alex Y Strongin
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依托单位:
CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME
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批准号:7725958
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项目类别:
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资助金额:$7.71万
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财政年份:2008
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负责人:Alex Y Strongin
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依托单位:
CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME
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批准号:7622856
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项目类别:
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资助金额:$7.39万
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财政年份:2007
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负责人:Alex Y Strongin
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依托单位:
Hydroxamate-based therapy to target T cell homing in IDDM
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批准号:7192269
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项目类别:
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资助金额:$23.88万
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财政年份:2006
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负责人:Alex Y Strongin
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依托单位:
Hydroxamate-based therapy to target T cell homing in IDDM
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批准号:7295821
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项目类别:
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资助金额:$27.82万
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财政年份:2006
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负责人:Alex Y Strongin
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依托单位:
CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME
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批准号:7167083
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项目类别:
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资助金额:$7.15万
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财政年份:2005
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负责人:Alex Y Strongin
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依托单位:
Structure-based Drug Design for Smallpox Therapy
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批准号:7242573
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项目类别:
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资助金额:$176.25万
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财政年份:2004
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负责人:Alex Y Strongin
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依托单位:
Structure-based Drug Design for Smallpox Therapy
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批准号:6915597
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项目类别:
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资助金额:$175.94万
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财政年份:2004
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负责人:Alex Y Strongin
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依托单位:
Structure-based Drug Design for Smallpox Therapy
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批准号:7095261
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项目类别:
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资助金额:$176.61万
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财政年份:2004
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负责人:Alex Y Strongin
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依托单位:
Structure-based Drug Design for Smallpox Therapy
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批准号:7437421
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项目类别:
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资助金额:$177.71万
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财政年份:2004
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负责人:Alex Y Strongin
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依托单位:
Structure-based Drug Design for Smallpox Therapy
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批准号:6816528
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项目类别:
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资助金额:$170.81万
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财政年份:2004
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负责人:Alex Y Strongin
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依托单位:
Develop Effective Inhibitors of Anthrax Lethal Factor
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批准号:6686659
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项目类别:
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资助金额:$49.97万
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财政年份:2003
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负责人:Alex Y Strongin
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依托单位:
Develop Effective Inhibitors of Anthrax Lethal Factor
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批准号:6778297
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项目类别:
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资助金额:$93.93万
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财政年份:2003
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负责人:Alex Y Strongin
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依托单位:
Develop Effective Inhibitors of Anthrax Lethal Factor
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批准号:7016283
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项目类别:
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资助金额:$92.04万
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财政年份:2003
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负责人:Alex Y Strongin
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依托单位:
Develop Effective Inhibitors of Anthrax Lethal Factor
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批准号:6872941
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项目类别:
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资助金额:$91.51万
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财政年份:2003
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负责人:Alex Y Strongin
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依托单位:
海外基金