CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 驱动生物学项目1：一种调节染色单体分离的蛋白分解途径。 有丝分裂过程中的染色体复制和分离是所有生命的中心。两国的分离 姐妹染色单体被认为是由一种名为分离酶的半胱氨酸蛋白酶控制的。然而，我们的 初步结果表明，至少还有另一种酶参与其中，即MT1-MMP.我们会 探讨染色单体参与蛋白水解级联反应的假说 有丝分裂过程中的分离。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 1: A Proteolytic Pathway that Regulates Chromatid Separation. Chromosomal duplication and separation during mitosis is central to all of life. The separation of sister chromatids is thought to be controlled by a cysteine protease, called separase. Yet our preliminary results indicate that at least one other protease is involved, MT1-MMP. We will investigate the hypothesis that a coordinated cascade of proteolysis is involved in chromatid separation during mitosis.