CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 驱动生物项目1：调节染色单体分离的蛋白水解途径。 有丝分裂过程中染色体的复制和分离是所有生命的核心。的分离 姐妹染色单体被认为是由一种叫做分离酶的半胱氨酸蛋白酶控制的。然而我们的 初步结果表明，至少涉及一种其它蛋白酶，MT 1-MMP。我们将 研究一个假设，即一个协调级联的蛋白水解参与染色单体 有丝分裂时的分离。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 1: A Proteolytic Pathway that Regulates Chromatid Separation. Chromosomal duplication and separation during mitosis is central to all of life. The separation of sister chromatids is thought to be controlled by a cysteine protease, called separase. Yet our preliminary results indicate that at least one other protease is involved, MT1-MMP. We will investigate the hypothesis that a coordinated cascade of proteolysis is involved in chromatid separation during mitosis.