COMPARATIVE HORMONAL EFFECTS OF DIETS CONTAINING SOY AND ANIMAL PROTEIN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。饮食与乳腺癌的病因和预防有关。有证据表明食用大豆可以降低患乳腺癌的风险。然而，大豆饮食中降低乳腺癌风险的有效成分尚不清楚。卵巢类固醇水平高与乳腺癌风险增加有关。目的：在之前的研究中，我们提供给研究对象的大豆饮食含有更高水平的大豆蛋白，但总蛋白含量低于我们的研究对象在无大豆家庭饮食中摄入的大豆蛋白。我们建议检验蛋白质的数量和来源都是影响绝经前妇女卵巢激素的关键决定因素的假设。方法：绝经前妇女将在三个不同的月经周期内食用相同的基础饮食，但将随机分为两组（每组10人，共20人），如下所示：一组饲喂6%大豆蛋白饮食，12%大豆蛋白饮食和对照饮食。另一组分别饲喂6%、12%牛肉蛋白饮食和对照饮食。两组的对照饮食是一样的，包括6%的大豆蛋白和6%的牛肉蛋白。大量的研究调查了饮食脂肪对卵巢激素水平的影响，结果不一。相比之下，很少有研究调查饮食蛋白质与卵巢激素或乳腺癌风险的关系。这项研究将在一定程度上填补这一知识空白。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diet has been implicated in the etiology and prevention of breast cancer. There is evidence to suggest that soy consumption may reduce the risk of breast cancer. However, the active component(s) of soy diets that reduce breast cancer risk are not known. High levels of ovarian steroids are associated with increased risk of breast cancer. Aims: The soy diet that we provided to our study subjects in prior studies contained higher levels of soy protein but less total protein than that consumed by our study subjects on soy-free home diets. We propose to test the hypothesis that the amount and the source of protein are both critical determinants in influencing ovarian hormones of premenopausal women. Methods: Premenopausal women will be placed on identical basal diets during three separate menstrual cycles but will be randomly allocated to two groups (10 per group, total 20) as follows: One group will be fed a 6% soy protein diet, a 12% soy protein diet and a control diet. The other group will be fed a 6% beef protein diet, 12% beef protein diet and a control diet. The control diet will be the same for both groups and will consist of 6% soy protein and 6% beef protein. Numerous studies have examined the effects of dietary fat on ovarian hormone levels, with variable results. In contrast, few studies have examined the relationship of dietary protein to ovarian hormones or breast cancer risk. This study will partly fill this knowledge gap.