COMPARATIVE HORMONAL EFFECTS OF DIETS CONTAINING SOY AND ANIMAL PROTEIN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。饮食被认为与乳腺癌的病因和预防有关。有证据表明，食用大豆可能会降低患乳腺癌的风险。然而，大豆饮食中降低乳腺癌风险的活性成分(S)尚不清楚。卵巢类固醇水平高与患乳腺癌的风险增加有关。目的：我们在之前的研究中提供给我们的研究对象的大豆饮食含有更高水平的大豆蛋白，但总蛋白含量低于我们研究对象在不含大豆的家庭饮食中摄入的大豆蛋白。我们建议检验蛋白质的数量和来源都是影响绝经前妇女卵巢激素的关键决定因素的假设。方法：绝经前妇女在三个不同的月经周期中接受相同的基础饮食，但随机分为两组(每组10人，共20人)：一组给予6%大豆蛋白饮食，12%大豆蛋白饮食，以及对照饮食。另一组饲喂6%牛肉蛋白日粮、12%牛肉蛋白日粮和对照日粮。两组的对照日粮相同，将由6%的大豆蛋白和6%的牛肉蛋白组成。许多研究考察了饮食脂肪对卵巢激素水平的影响，结果各不相同。相比之下，很少有研究研究饮食蛋白质与卵巢激素或乳腺癌风险的关系。这项研究将在一定程度上填补这一知识空白。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diet has been implicated in the etiology and prevention of breast cancer. There is evidence to suggest that soy consumption may reduce the risk of breast cancer. However, the active component(s) of soy diets that reduce breast cancer risk are not known. High levels of ovarian steroids are associated with increased risk of breast cancer. Aims: The soy diet that we provided to our study subjects in prior studies contained higher levels of soy protein but less total protein than that consumed by our study subjects on soy-free home diets. We propose to test the hypothesis that the amount and the source of protein are both critical determinants in influencing ovarian hormones of premenopausal women. Methods: Premenopausal women will be placed on identical basal diets during three separate menstrual cycles but will be randomly allocated to two groups (10 per group, total 20) as follows: One group will be fed a 6% soy protein diet, a 12% soy protein diet and a control diet. The other group will be fed a 6% beef protein diet, 12% beef protein diet and a control diet. The control diet will be the same for both groups and will consist of 6% soy protein and 6% beef protein. Numerous studies have examined the effects of dietary fat on ovarian hormone levels, with variable results. In contrast, few studies have examined the relationship of dietary protein to ovarian hormones or breast cancer risk. This study will partly fill this knowledge gap.