COMPARING THE RESPONSE RATE OF AN ACCELERATED VACCINATION SCHEDULE USING A

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是在慢性丙型肝炎患者中使用甲型和乙型肝炎的加速接种剂量计划，并将他们的反应与以完全相同的方式接种的健康患者进行比较。我们将使用的疫苗是一种联合疫苗，这意味着它可以预防甲型和乙型肝炎病毒。这个项目背后的想法是我们相信丙型肝炎的反应受到一些损害，没有健康人那么有效。我们想找出这种加速的疫苗接种时间表是否可以改善对这些疫苗的反应。此外，我们想知道这个疫苗接种时间表是否可以用于为不断迁徙的人口快速接种疫苗，比如德克萨斯州和美国边境的人口。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of the study is to use an accelerated vaccination dosing chedule for Hepatitis A and B in patients with chronic Hepatitis C and compare their response to healthy patients vaccinated in exactly the same way. The vaccine that we will be using is a combination vaccine, which means it protects against both types of Hepatitis A and B viruses. The idea behind this project is our belief that the response in Hepatitis C is somewhat impaired and not as effective as in healthy people. We want to find out whether this accelerated vaccination schedule can improve the response to these vaccines. In addition we want to find out if this vaccination schedule can be used to rapidly vaccinate populations who are constantly migrating, such as that of the Texas American border.