THE ROLE OF PROBIOTIC SUPPLEMENTS IN THE TREATMENT OF ATOPIC DERMATITIS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。对食物过敏反应的基础是过敏原穿过高渗透性肠粘膜的摄取。据推测，通过密封肠的桥粒，REPGG将防止过敏原渗漏，从而改善食物过敏患者的特应性皮炎。 将招募患有严重湿疹和多种食物过敏的1-8岁儿童患者（共24例可评价患者）。将使用SCORAD指数测量特应性皮炎的严重程度。将通过蔗糖、乳果糖和甘露醇排泄的高效液体测量来分析肠渗透性。患者将空腹并消耗基于体重的甘露醇/乳果糖/蔗糖体积，随后采集5小时尿液以测定每种物质的尿排泄。然后将患者随机分配至基于体重的每日摄入RIGGG或安慰剂组，持续6周，之后他们将在禁食过夜后返回，以进行重复的蔗糖/乳果糖/甘露醇摄入和尿排泄评估。 预期通过定植肠植物群和促进内源性屏障机制，BEGG将被证明是治疗具有食物过敏病因的特应性皮炎的有用工具，并且肠通透性变化和特应性临床改善之间存在相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A basis of the allergic response to a food is uptake of allergens across hyperpermeable intestinal mucosa. It is hypothesized that lactobacillus GG, by sealing the desmosomes of bowel, will prevent allergen leakage, resulting in improvement of atopic dermatitis in patients with food allergies. Pediatric patients ages 1-8 (a total of 24 evaluable patients to be studied) with severe eczema and multiple food allergies will be recruited. Severity of atopic dermatitis will be measured using the SCORAD Index. Intestinal permeability will be analyzed by high performance liquid measurement of sucrose, lactulose and mannitol excretion. Patients will present fasting and consume a weight based volume of mannitol/lactulose/sucrose with a subsequent five hour urine collection for determination of urinary excretion of each. Patients will then be randomly assigned to either a weight based daily ingestion of lactobacillus GG or placebo for six weeks, afterwards they will return after overnight fasting for a repeat sucrose/lactulose/mannitol ingestion and urinary excretion evaluation. It is anticipated that lactobacillus GG, by colonizing bowel flora and promoting endogenous barrier mechanisms will prove to be a useful tool in treating atopic dermatitis that has a food allergy etiology and that a correlation will exist between changes in intestinal permeability and clinical improvement of atopy.