EFFECTS OF SIMULATED MICROGRAVITY ON THE ANESTHETIC PROPERTIES OF PROPOFOL

模拟微重力对异丙酚麻醉性能的影响

• 批准号: 7374645
• 负责人: CHRISTOPHER SEUBERT
• 金额: $ 12.61万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374645
• 关键词: EFFECTS; SIMULATED; MICROGRAVITY; ANESTHETIC; PROPERTIES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite careful health screening by NASA, astronauts adapted to microgravity might require the administration of anesthesia for a variety of surgical conditions not only in the highly autonomous environments of space habitation or Mars-type missions but also for immediate surgical care after evacuation from low orbital missions. A paucity of information is available regarding the most appropriate anesthetic technique in microgravity. Physiologic adaptation to weightlessness (e.g., changes in blood and plasma volume, fraction of cardiac output directed to brain, autonomic nervous system activity) can be expected to markedly alter the in vivo behavior and characteristics of anesthetics/hypnotics. Total intravenous anesthesia (TIVA) is probably the most practical and cost-effective method of rendering subjects insensate during surgery under microgravity conditions and at remote locations. Equipment for TIVA is light, compact, and self-contained. Among the TIVA agents in use today, propofol (2, 6-diisopropylphenol) is the best single agent suitable for use in space. Propofol has several key properties that make it a desirable anesthetic in a space environment: 1) rapid induction of and emergence from anesthesia, 2) ability to adjust the dose to achieve anesthetic states ranging from conscious sedation to general anesthesia, 3) lack of drug accumulation in the body, even during long procedures, 4) significant anti-emetic properties, and 5) a simple and reliable means for assessing the depth of anesthesia/hypnosis, the bispectral index (BIS), derived from the electrical activity of the brain. We hypothesize that 1) adaptation to microgravity increases the hypnotic/anesthetic effect of propofol by changing its pharmacokinetics (PK), but not pharmacodynamics (PD) and 2) adaptation to microgravity does not change the recovery of cognitive function after propofol anesthesia. In order to devise a rational strategy for providing anesthesia capabilities in the context of space flight, we plan to test these hypotheses in a prospective, randomized crossover study of volunteers by using an earth-based simulation of microgravity.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。尽管美国宇航局进行了仔细的健康检查，适应微重力的宇航员可能需要在各种手术条件下进行麻醉，不仅在太空居住或火星类任务的高度自主环境中，而且在从低轨道任务撤离后立即进行手术护理。关于微重力下最合适的麻醉技术的信息很少。对失重的生理适应（例如，血液和血浆容量的变化、流向大脑的心输出量分数、自主神经系统活动）预计会显着改变麻醉剂/催眠剂的体内行为和特征。全静脉麻醉 (TIVA) 可能是在微重力条件下和偏远地点进行手术期间使受试者失去知觉的最实用且最具成本效益的方法。 TIVA 设备轻便、紧凑且独立。在当今使用的 TIVA 药剂中，丙泊酚（2, 6-二异丙基苯酚）是最适合在太空使用的单一药剂。丙泊酚具有几个关键特性，使其成为太空环境中理想的麻醉剂：1) 快速诱导和苏醒，2) 能够调整剂量以实现从清醒镇静到全身麻醉的麻醉状态，3) 即使在长时间手术过程中，体内也不会积聚，4) 显着的止吐特性，以及 5) 一种简单可靠的评估麻醉深度的方法。 麻醉/催眠，脑电双频指数（BIS），源自大脑的电活动。我们假设：1）适应微重力通过改变其药代动力学（PK）而不是药效学（PD）来增加异丙酚的催眠/麻醉效果，2）适应微重力不会改变异丙酚麻醉后认知功能的恢复。为了制定在太空飞行中提供麻醉能力的合理策略，我们计划通过使用基于地球的微重力模拟，在志愿者的前瞻性、随机交叉研究中测试这些假设。