BIOMAGNETIC CHARACTERIZATION OF GASTRIC DYSRHYTHMIAS

胃节律失常的生物磁学特征

• 批准号: 7375579
• 负责人: LEONARD A BRADSHAW
• 金额: $ 0.08万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375579
• 关键词: BIOMAGNETIC; CHARACTERIZATION; GASTRIC; DYSRHYTHMIAS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS(ES): 1) Gastric electrical activity (GEA) propagates in the smooth muscle syncytium of the stomach in regular spatiotemporal patterns. 2) Internal gastric electrical patterns in normal tissue produce regular external gastric magnetic field patterns. 3) Gastric electrical patterns in normal humans produce regular spatiotemporal patterns in multichannel external magnetic field recordings. 4) Gastric dysrhythmias resulting from mechanical uncoupling of the gastric syncytium produce irregular spatiotemporal patterns in recordings of both internal serosal potentials and external magnetic fields. 5) Autonomic disorders known to cause gastric dysrhythmias result in abnormal gastric magnetic field spatiotemporal patterns. 6) Patients w/diabetic gastroparesis exhibit abonormal postprandial gastric magnetic field patterns compared to normal volunteers. SPECIFIC AIMS: 1) Characterize magnetic patterns of GEA in normal human volunteers. 2) Characterize the effect of autonomic disorders on gastric magnetic field patterns. 3) Characterize the magnetic signature of diabetic gastroparesis.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。假设：1）胃电活动（GEA）在胃平滑肌合胞体中以有规律的时空模式传播。2)正常组织的内部胃电模式产生规则的外部胃磁场模式。3)正常人的胃电模式在多通道外部磁场记录中产生规则的时空模式。4)由胃合胞体的机械解偶联引起的胃节律紊乱在内部血清电位和外部磁场的记录中产生不规则的时空模式。5)已知引起胃节律紊乱的自主神经紊乱导致异常胃磁场时空模式。6)与正常志愿者相比，糖尿病胃轻瘫患者餐后胃磁场模式异常。具体目的：1）表征正常人类志愿者GEA的磁性模式。2)描述自主神经紊乱对胃磁场模式的影响。3)描述糖尿病胃轻瘫的磁特征。