BIOMAGNETIC CHARACTERIZATION OF GASTRIC DYSRHYTHMIAS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。假设(ES)：1)胃电活动(GEA)在胃的平滑肌合体中以规则的时空模式传播。2)正常组织内的胃电模式产生规律性的胃外磁场模式。3)正常人的胃电模式在多通道外磁场记录中产生规律性的时空模式。4)由胃合体机械解偶联引起的胃电节律紊乱，在记录的浆膜内电位和外磁场中都会产生不规则的时空模式。5)已知的引起胃电节律紊乱的自主神经障碍会导致异常的胃磁场时空模式。6)糖尿病胃轻瘫患者的餐后胃磁场模式与正常人相比有明显的异常。具体目的：1)研究正常人脑电地形图的磁模式。2)表征自主神经紊乱对胃磁场模式的影响。3)描述糖尿病胃轻瘫的磁学征象。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS(ES): 1) Gastric electrical activity (GEA) propagates in the smooth muscle syncytium of the stomach in regular spatiotemporal patterns. 2) Internal gastric electrical patterns in normal tissue produce regular external gastric magnetic field patterns. 3) Gastric electrical patterns in normal humans produce regular spatiotemporal patterns in multichannel external magnetic field recordings. 4) Gastric dysrhythmias resulting from mechanical uncoupling of the gastric syncytium produce irregular spatiotemporal patterns in recordings of both internal serosal potentials and external magnetic fields. 5) Autonomic disorders known to cause gastric dysrhythmias result in abnormal gastric magnetic field spatiotemporal patterns. 6) Patients w/diabetic gastroparesis exhibit abonormal postprandial gastric magnetic field patterns compared to normal volunteers. SPECIFIC AIMS: 1) Characterize magnetic patterns of GEA in normal human volunteers. 2) Characterize the effect of autonomic disorders on gastric magnetic field patterns. 3) Characterize the magnetic signature of diabetic gastroparesis.