BIOMAGNETIC CHARACTERIZATION OF GASTRIC DYSRHYTHMIAS

胃节律失常的生物磁学特征

• 批准号: 6856958
• 负责人: LEONARD A BRADSHAW
• 金额: $ 4.99万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6856958
• 关键词: biomagnetism; biomagnetism measurement; clinical research; diabetes mellitus; diagnosis design /evaluation; electrical measurement; electrophysiology; human subject; laboratory rabbit; magnetic field; noninvasive diagnosis; paralysis; stomach; stomach motility /pressure

DESCRIPTION (Verbatim from Applicant's Abstract): In normal subjects, the gastric electrical activity (GEA) consists of a 3 cycle-per-minute slow wave known as the , electrical control activity (ECA). While cutaneous electrodes placed on the surface of the abdomen can record GEA, determination of frequency is the only reliable parameter available from the cutaneous electrogastrogram (EGG). The magnetogastrogram (MGG), the measurement of magnetic fields from GEA, may have greater clinical value than the EGG since gastric magnetic fields reflect the smooth muscle ECA more accurately than the EGG. Low-conductivity tissue layers present in the abdomen serve to smooth and attenuate the electric potential from GEA sources, resulting in a cutaneous EGG that is a spatial summation of many different bioelectric sources. The purpose of this project is to characterize normal and abnormal gastric electrical activity by noninvasive examination of the externally-recorded MGG. We hypothesize that GEA produces regular| spatiotemporal magnetic field patterns that characterize the health status of gastric smooth muscle. Whereas healthy gastric smooth muscle is electrically coupled and allows GEA to propagate from the antral pacemaker site toward the pylorus, we hypothesize that disorders that uncouple gastric smooth muscle disrupt the regular GEA propagation patterns. We hypothesize that spatiotemporal patterns in multi-channel MGG recordings will correlate strongly with the underlying GEA and that they will change under abnormal conditions, reflecting the underlying GEA. We will measure normal serosal potentials and magnetic fields and compare these with data from (1) the mechanically divided stomach, (2) GEA released from autonomic vagal influence, (3) pharmacologically-induced gastric dysrhythmias, and (4) patients with diabetic gastroparesis. If successful, our studies will represent the first characterization of biomagnetic signatures of abnormal gastric function. In addition to improving our understanding of the basic science of gastric electrophysiology, these studies will significantly advance our goal to introduce this method as a routine clinical tool, providing physicians with a noninvasive assessment of the function of the stomach.

描述（来自申请人摘要的逐字）：在正常受试者中， 胃电活动（GEA）由每分钟3个周期的慢波组成 这就是所谓的电气控制活动（ECA）。虽然皮肤电极 放置在腹部表面可以记录GEA，测定频率 是皮肤胃电图中唯一可靠的参数 （EGG）。胃磁图（MGG），测量来自 GEA可能比EGG具有更大的临床价值，因为胃磁场 比EGG更准确地反映平滑肌ECA。低导电 存在于腹部中的组织层用于平滑和衰减电传导， 来自GEA源的电位，导致皮肤EGG是空间的 许多不同的生物电源的总和。本项目的目的是 通过非侵入性测量来表征正常和异常胃电活动， 检查外部记录的MGG。我们假设GEA产生 定期|表征健康状况的时空磁场模式 胃平滑肌状态。而健康的胃平滑肌 电耦合，并允许GEA从胃窦起搏点传播 朝向幽门，我们假设， 肌肉破坏了正常的GEA传播模式。我们假设 多通道MGG记录中的时空模式将强烈相关 与潜在的GEA，他们将在异常条件下改变， 反映了潜在的GEA。我们将测量正常的血清学电位， 磁场，并将这些数据与（1）机械划分的 胃，（2）自主迷走神经影响释放的GEA，（3） 药理学诱导的胃节律紊乱，和（4）糖尿病患者 胃轻瘫如果成功，我们的研究将成为 胃功能异常的生物磁性特征的表征。在 除了提高我们对胃的基础科学的理解， 电生理学，这些研究将大大推进我们的目标， 介绍这种方法作为一种常规的临床工具，为医生提供一个 胃功能的非侵入性评估。