ACETAMINOPHEN AND ASTHMA

对乙酰氨基酚和哮喘

• 批准号: 7375672
• 负责人: JAMES R SHELLER
• 金额: $ 2.14万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375672
• 关键词: ACETAMINOPHEN; ASTHMA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1. Prolonged use of acetaminophen in therapeutic doses provokes oxidative stress in human airways. 2. Prolonged use of therapeutic doses of acetaminophen results in increased concentrations of bronchoconstricting prostanoids in human airways. Specific aims 1. To test the hypothesis that chronic use of acetaminophen in therapeutic doses provokes oxidative stress in the airways in normal and asthmatic human subjects. 2. To test the hypothesis that chronic use of therapeutic doses of acetaminophen causes inhibition of prostacyclin and increases thromboxane A2 levels in the airways in normal and asthmatic subjects.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。1.长期使用治疗剂量的对乙酰氨基酚会引起人体气道的氧化应激。 2.长期使用治疗剂量的对乙酰氨基酚会导致人气道中收缩支气管的前列腺素类浓度增加。 具体目标1。检验长期使用治疗剂量的对乙酰氨基酚在正常和哮喘人类受试者的气道中引起氧化应激的假设。 2.检验长期使用治疗剂量的对乙酰氨基酚导致正常和哮喘受试者气道中前列环素抑制和血栓素A2水平升高的假设。