EFFECT OF ACUTE E PROSTAGLANDIN AGONIST N BAL EICO

急性 E 型前列腺素激动剂 N BAL EICO 的作用

• 批准号: 6115624
• 负责人: JAMES R SHELLER
• 金额: $ 3.64万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115624
• 关键词: allergens; atopy; cell population study; clinical research; drug screening /evaluation; human subject; human therapy evaluation; oral administration; prostaglandin E; prostaglandin analogs; respiratory hypersensitivity

To determine the effect of a single oral administration of the PGE1 analog, Misoprostol, on mediator release and airway cell population changes caused by instilled allergen in sensitive atopic subjects and the effect of a single inhaled dose of the PGE2 compound, Prostin E2 on mediator release and airway cell population changes caused by instilled allergen in sensitive atopic subjects. This pilot study has completed enrollment and data analysis is forthcoming.

确定PGE1单次口服给药的效果 类似物米索前列醇对介质释放和气道细胞群的影响 在敏感的特应性受试者中由滴注过敏原引起的变化， 单次吸入剂量的PGE2化合物，前列腺素E2， 介体释放和气道细胞数量的变化 过敏性特应性个体过敏原。 该初步研究已完成入组和数据分析， 即将到来。