A MULITCENTER, DOUBLE-BLIND, PILOT STUDY OF MINOCYCLINE AND CREATINE IN SUBJ

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific aims: to determine whether minocycline will drecrease the number of PD subjects who clinically worsen over a two-year period, compared to placebo. to determine whether creatine will drcrease the number of PD subjects who clinically worsen over a two - year period, compared to placebo.