Parkinson's Disease Neuroprotection Clinical Centers

描述（由申请人提供）：正如本RFA （RFA- ns -02-010）公告所述，该项目的目的是创建一个临床中心，用于开展帕金森病神经保护的未来临床试验。本网站有三名在运动障碍方面受过专业训练的神经科专家，他们将参与这个拟议的项目。在这个项目实施后，这些神经科医生将合作进行一项预防PD疾病进展的药物的试点试验。随后，与其他临床中心站点的额外合作将导致至少一个多中心试验。

DESCRIPTION (provided by applicant): As outlined in this RFA (RFA-NS-02-010) announcement, the aims of this project are to create a clinical center for the conduct of future clinical trials of neuroprotection for Parkinson's disease. This site has three board-certified neurologists trained in movement disorders who will participate in this proposed project. Upon implementation of this project these neurologists will collaborate to conduct a pilot trial of an agent to prevent disease progression in PD. Subsequently, additional collaboration with the other clinical center sites will lead to at least one multicenter trial. This project will help to maintain a stable infrastructure for the administration of the clinical trial(s) in neuroprotection related to Parkinson's disease. In addition, the conduct of this type of clinical trial(s) will generate a sample of patients with early PD who may be willing to participate in genetic studies. Similarly, subjects may be willing to participate in studies to identify markers from blood or cerebrospinal fluid that may indicate disease presence or severity. This research may lead to a greater understanding of PD and better treatments.