GHRELIN LEVELS WITH ORAL VS PER TUBE MEALS AFTER RYGB

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims 1. Determine the time-dependent impact of gastric division on ghrelin release in the morbidly obese patient. 2. Determine whether gastric division with resultant fundic isolation during RYGB would alter the pattern(s) of ghrelin secretion in the early post-operative period following feeding in morbidly obese subjects. 3. Determine the potential role of the fundus in mediating the diurnal variation in plasma ghrelin levels.