HIV-PNEUMONIAE IMMUNITY STUDY

HIV-肺炎免疫研究

• 批准号: 7381056
• 负责人: Vladimir Berthaud
• 金额: $ 9.69万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381056
• 关键词: HIV; PNEUMONIAE; IMMUNITY; STUDY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a 2:1 matched case-control study to span over the first 2 years of the grant. Cases are all patients with apositive culture for S. pneumoniae isolated from sputum or any sterile sites. The cases and controls will be stratified by age and history of previous pneumococcal vaccination. Moreover, HIV-seropositive patients will be matched by CD4 lymphocyte count stratum for subgroup analysis. Based on our preliminary data, we expect to enroll a total of 180 subjects in the case-control study, including drop-outs and withdrawals. We will use two-sample t-test or Mann-Whitney U test to compare antibody levels and their functionality between blacks and non-blacks In a multipe regression model, we will assess risk factors and outcome dterminants for invasive pneumococcal disease and infectios with penicillin resistant S. pneumoniae. Study subjects will be recruit among patients hospitalized at Nashville General Hospital, a tertiary academic medical center.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项2：1匹配的病例对照研究，涵盖赠款的前2年。例均为S.从痰或任何无菌部位分离的肺炎。病例和对照将按年龄和既往肺炎球菌疫苗接种史分层。此外，HIV血清阳性患者将通过CD 4淋巴细胞计数分层进行匹配，以进行亚组分析。根据我们的初步数据，我们预计病例对照研究共招募180例受试者，包括脱落和退出。我们将使用两样本t检验或Mann-Whitney U检验来比较黑人和非黑人之间的抗体水平及其功能性。在多元回归模型中，我们将评估侵袭性肺炎球菌疾病和青霉素耐药链球菌感染的危险因素和结局决定因素。肺炎。研究受试者将从纳什维尔综合医院（一家三级学术医疗中心）住院的患者中招募。