IMMUNITY TO S PNEUMONIAE VACCINE IN HIV-INFECTED AFRICAN-AMERICANS

感染艾滋病毒的非洲裔美国人对肺炎链球菌疫苗的免疫力

• 批准号: 7380794
• 负责人: Vladimir Berthaud
• 金额: $ 49.74万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380794
• 关键词: IMMUNITY; PNEUMONIAE; VACCINE; HIV; INFECTED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV infected African-American adults have low levels of immunity to Streptococcus pneumoniae capsular polysaccharide (serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F). The currently recommended 23-valent pneumococcal polysaccharide vaccine does not offer very good protection against invasive pneumococcal disease. Experience with the more immunogenic conjugate pneumococcal heptavalent vaccine in HIV-infected African-American adults is limited. Our hypothesis is that they will have higher immune response to pneumococcal conjugate vaccine (CPV) than to pneumococcal polysaccharide vaccine (PPV). Specific Aims; 1) To determine antibody levels to serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F of Streptococcus pneumoniae capsular polysaccharide (PPS) in HIV-infected Blacks 2) To determine the functional antibody response by opsonophagocytic assay (OPA) 3) To determine the correlation between the patient serotype-specific immunity and S. pneumoniae serotype isolated from blood culture 4) To correlate antibody levels with immunologic and virologic parameters 5) To determine immunity generated in HIV-infected adults against sequential vaccination with conjugate pneumococcal heptavalent vaccine (CPV) and 23-valent pneumococcal polysaccharide vaccine (PPV) as compared with single-dose pneumococcal polysaccharide vaccine.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。感染HIV的非裔美国成年人对肺炎链球菌荚膜多糖(血清型4、6B、9V、14、18C、19F和23F型)的免疫力较低。目前推荐的23价肺炎球菌多糖疫苗对侵袭性肺炎球菌疾病没有很好的保护作用。在感染艾滋病毒的非裔美国成年人中使用更具免疫原性的肺炎球菌七价结合疫苗的经验有限。我们的假设是，它们对肺炎球菌结合疫苗(CPV)的免疫应答高于对肺炎球菌多糖疫苗(PPV)的免疫应答。目的：1)检测HIV感染黑人对肺炎链球菌荚膜多糖(PPS)血清型4、6B、9V、14、18C、19F和23F型的抗体水平；2)通过噬液细胞分析(OPA)3)确定患者血清型特异性免疫与从血培养中分离的肺炎链球菌血清型之间的相关性；4)抗体水平与免疫学和病毒学参数的相关性5)以确定HIV感染者对连续接种七价肺炎球菌疫苗(CPV)和23价肺炎球菌多糖疫苗(PPV)产生的免疫力，并与单剂肺炎球菌多糖疫苗(PPV)进行比较。