MODELING HUMAN BREAST CANCER IN SWINE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。正常人的乳房发育经历了一个复杂的过程，在细胞分化和乳汁合成之前，这一过程涉及到协调的几轮上皮细胞增殖和形态形成。为了了解乳腺癌的基础，首先必须了解调节这些正常过程的机制。虽然利用啮齿动物模型已经取得了重大进展，但一个主要限制是这些物种的正常乳腺发育和肿瘤发生与人类并不十分相似。在一项正在进行的开发人类乳腺癌替代动物模型的努力中，我们已经鉴定出其他大型动物物种的乳腺具有与人类乳腺相似的特征。拟议的工作将提供研究生培训，旨在进一步评估该模型的荷尔蒙调节。具体地说，硕士候选人将有机会测试这一假设，即各种激素改变大型动物物种乳腺的生长和形态发生。最终，这一规定的定义可能有助于提供一个真实的人类乳房模型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The normal human breast develops through a complex process that involves coordinated rounds of epithelial proliferation and morphogenesis prior to cellular differentiation and milk synthesis. In order to understand the basis of breast cancer it is first necessary to understand the mechanisms that regulate these normal processes. While significant gains have been made using rodent models, a major limitation is that normal mammary development and tumorigenesis in these species does not closely resemble that in humans. In an ongoing effort to develop an alternative animal model for human breast cancer, we have identified that the mammary glands of other large animal species have features similar to the human breast. The work proposed will provide graduate training designed to further evaluate the hormonal regulation of this model. Specifically, a Masters candidate will have the opportunity to test the hypothesis that various hormones alter growth and morphogenesis of the mammary glands in large animal species. Ultimately the definition of this regulation could help to afford an authentic model of the human breast.