REGULATION OF CADHERIN EXPRESSION IN THE NEURAL CREST BY THE WNT/B-CATENIN SIGNA

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本实验室的主要重点是解决神经嵴细胞发育中的钙粘蛋白的作用，包括调节神经嵴细胞形态发生中钙粘蛋白的表达和功能的分子基础和特定的钙粘蛋白在神经嵴细胞发育中的作用的评估。这个COBRE试点项目赠款提案是嵌入在实验室的第一个主要研究重点。在神经发生早期，Wnt和BMP信号在神经和非神经外胚层之间的边界处诱导神经嵴。这两个主要的信号通路参与了神经嵴细胞发育的多个点。在这些过程中，细胞行为发生了复杂的变化，包括细胞间粘附和迁移行为的变化。由于细胞粘附蛋白，钙粘蛋白，经历动态变化的表达模式，他们可能是这些信号通路的目标。这个为期一年的试点项目提案的具体目标是解决神经嵴细胞发育中Wnt信号通路对钙粘蛋白表达的调节。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main focus of this lab is to address the role of cadherins in neural crest cell development, including the molecular basis for regulation of cadherin expression and function in neural crest cell morphogenesis and the evaluation of the role of specific cadherins in neural crest cell development. This COBRE Pilot Project Grant proposal is embedded in the first major research focus of the lab. The neural crest is induced at the border between the neural and non-neural ectoderm during early neurogenesis by Wnt and BMP signals. These two main signaling pathways are involved at multiple points in neural crest cell development. There are complicated changes in cell behavior during these processes that include changes in cell-cell adhesion and migratory behavior. As the cell adhesion proteins, cadherins, undergo dynamic changes in expression patterns, they are likely targets of these signaling pathways. The specific aims of this one year pilot project proposal address the regulation of cadherin expression by the Wnt signaling pathway in neural crest cell development.