Physiological significance of changes in cadherin expression during vocal learning in songbirds

为了研究ii型钙粘蛋白在神经可塑性中的功能，我对鸣禽孟加拉雀的鸣叫发育进行了体内分析，并对大鼠海马培养神经元进行了体外分析。这些研究结果表明，钙粘蛋白在RA声核中的表达变化从cadherin-7到cadherin-6B增加了脊髓的数量，从而控制了鸣禽声音学习所必需的神经元可塑性。

To examine the function of type-II cadherins in neural plasticity, here, I performed in vivo analysis of song development of a songbird, Bengalese finch and in vitro analysis of rat hippocampal cultured neurons. The results of these studies suggest that expression change of cadherins from cadherin-7 to cadherin-6B in the RA vocal nucleus increases the number of spines to control neuronal plasticity essential for vocal learning of a songbird in a trial and error manner.