CHARACTERIZATION OF TOLLOID-LIKE PROTEIN IN REPTILE AND ITS ROLE IN SYNAPTIC PLA

爬行动物中 Tolloid 样蛋白的表征及其在突触 PLA 中的作用

• 批准号: 7381112
• 负责人: BORIS SABIRZHANOV
• 金额: $ 1.68万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381112
• 关键词: CHARACTERIZATION; TOLLOID; LIKE; PROTEIN; REPTILE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Learning and memory is associated with morphological changes such as the birth of new neurons (neurogenesis) or the growth and formation of new dendritic spines or synaptic contacts (synaptogenesis). Such long-term changes in the nervous system involve neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and the bone morphogenetic proteins (BMPs). The actions of the BMPs are regulated, at least in part by members of the Tolloid family of metalloproteases. Tolloid family proteins are pleiotropic, astacin-like metalloproteases. There are four known mammalian Tolloid proteins: BMP-1, mammalian Tolloid (mTLD), mammalian Tolloid-like 1 (Tll-1), and mammalian Tolloid-like 2 (Tll-2). Two members of the family, BMP-1 and Tll-1, allow the potentiation of BMP signaling. We hypothesize that mammalian Tolloid proteins may function as a local potentiator of synaptogenesis during learning by regulating BMP signaling.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。学习和记忆与形态学变化有关，如新神经元的诞生（神经发生）或新树突棘或突触接触的生长和形成（突触发生）。神经系统的这种长期变化涉及神经营养因子，如脑源性神经营养因子（BDNF）和骨形态发生蛋白（BMP）。BMP的作用至少部分地由金属蛋白酶的Tolloid家族的成员调节。Tolloid家族蛋白质是多效性的、虾红素样金属蛋白酶。存在四种已知的哺乳动物Tolloid蛋白：BMP-1、哺乳动物Tolloid（mammalian Tolloid）、哺乳动物Tolloid样1（Tll-1）和哺乳动物Tolloid样2（Tll-2）。该家族的两个成员BMP-1和Tll-1允许BMP信号传导的增强。我们推测哺乳动物Tolloid蛋白可能在学习过程中通过调节BMP信号传导作为突触发生的局部增强剂。