CHARACTERIZATION OF TOLLOID-LIKE PROTEIN IN REPTILE AND ITS ROLE IN SYNAPTIC PLA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。学习和记忆与形态变化有关，如新神经元的诞生（神经发生）或新树突棘或突触接触的生长和形成（突触发生）。这种神经系统的长期变化涉及神经营养因子，如脑源性神经营养因子（BDNF）和骨形态发生蛋白（BMPs）。bmp的作用至少部分是由金属蛋白酶的Tolloid家族成员调节的。Tolloid家族蛋白是多效性的astastin样金属蛋白酶。哺乳动物有四种已知的Tolloid蛋白：BMP-1，哺乳动物Tolloid (mTLD)，哺乳动物Tolloid样1 （Tll-1）和哺乳动物Tolloid样2 （Tll-2）。该家族的两个成员BMP-1和Tll-1可以增强BMP信号。我们假设哺乳动物的绒毛蛋白可能通过调节BMP信号在学习过程中作为突触发生的局部增强剂起作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Learning and memory is associated with morphological changes such as the birth of new neurons (neurogenesis) or the growth and formation of new dendritic spines or synaptic contacts (synaptogenesis). Such long-term changes in the nervous system involve neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and the bone morphogenetic proteins (BMPs). The actions of the BMPs are regulated, at least in part by members of the Tolloid family of metalloproteases. Tolloid family proteins are pleiotropic, astacin-like metalloproteases. There are four known mammalian Tolloid proteins: BMP-1, mammalian Tolloid (mTLD), mammalian Tolloid-like 1 (Tll-1), and mammalian Tolloid-like 2 (Tll-2). Two members of the family, BMP-1 and Tll-1, allow the potentiation of BMP signaling. We hypothesize that mammalian Tolloid proteins may function as a local potentiator of synaptogenesis during learning by regulating BMP signaling.